A Method for Inhibiting Complement Activation during Organ Transplantation (BIDMC 623)

Category:    Therapeutics - Methods

KeyWords:  Transplantation;  

BIDMC ID:    623

Abstract:

The complement system is a complex interaction of plasma proteins and membrane cofactors which act in a multi-step, multi-protein cascade sequence in conjunction with other immunological systems of the body to provide immunity from intrusion of foreign cells. In the field of organ transplantation there continues to be a significant problem with organ rejection. A method of inhibiting complement activation, particularly by a transplanted organ. The method includes administering a therapeutically effective amount of a platlet activity modulator before, during or after a transplant. The inventors have described The interaction between platelets and the coagulation pathway components are believed to play a role in the initiation of the organ rejection pathway, which has been established to occur through the activation of complement.

Inventor:   Simon Robson, BIDMC, Richard N. Pierson III, Vanderbilt, George L. Zorn III, Vanderbilt, Todd D. Giorgio, Vanderbilt and Agnes M. Azimzadeh, Vanderbilt

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Related Technology URL:

http://research.bidmc.harvard.edu/research/ResearchPIInfo.ASP?Submit=Display&PersonID=590

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TVO Contact Info:
     Catherine M Lenich
     Senior Associate TVO
     clenich@bidmc.harvard.edu
     Phone: 617-667-0568   Fax: 617-667-0646

     Beth Israel Deaconess Medical Center
     Technology Ventures Office  Room: BR-0200
     330 Brookline Avenue
     Boston, MA 02215