Global Risk Reduction 
Relative Risk for Complications
Tight Metabolic Control Reducing Risk for Progression
Diabetes Control and Complications Trial
DCCT: Intensive Therapy vs. Conventional Therapy
United Kingdom Prospective Diabetes Study
UKPDS: Results
UKPDS: Obese Patients
Other Cardiovascular Risk Factors
Diabetes as a Cardiovascular Risk Equivalent
Cardiovascular Risk and Type 2 Diabetes
Treatment of Hypertension as a Cardiovascular Risk Factor
UKPDS: Result of Blood Pressure Control
ACEI as First-Line Therapy to Treat Hypertension in Diabetes
ARB as First-Line Therapy to Treat Hypertension in Diabetes
Treatment of Hyperlipidemia as a Cardiovascular Risk Factor
Non Glycemic Goals in Patients with Type 2 Diabetes
Intensive Multifactorial Therapy and Cardiovascular Events
Intensive Multifactorial Therapy and Microvascular Events
Percent of Patients Who Achieve Target Goals
to the Tutorial List
Relative Risk for Complications
Complication
Relative Risk
Myocardial infarction
2-4X
Amputation
2-4X
End-stage renal disease
10X
Blindness
25X


The longterm complications of diabetes include retinopathy, nephropathy and neuropathy (microvascular complications) and coronary artery, peripheral vascular and cerebrovascular disease (macrovascular complications). Diabetes is the leading cause of end stage renal disease and blindness in the Western World. Coronary artery disease is the leading cause of death in patients with diabetes.