Prophylactic Treatment of Migraine 
Introduction
When is Prophylaxis Appropriate?
Reasonable Goals for Prophylaxis
Classes of Pharmacologic Treatment
Selection of a Prophylactic Drug
Beta Adrenergic Blockers
Tricyclic Antidepressants
Anticonvulsants
Calcium Channels Blockers
Nonsteroidal Anti-inflammatory Drugs (NSAIDS)
5-HT Antagonists and Agonists
Nutritional Supplements
Concurrent Use of Acute and Prophylactic Treatments
Non-Pharmacological Therapies
Summary
References
to the Tutorial List
Introduction
Prophylactic treatment of migraine is treatment designed to decrease the frequency and severity of migraine attacks. A wide variety of pharmacological and non-pharmacological therapies are available and the choice of drug should depend upon individual situation and other co-existing medical problems.

Pharmacological agents are taken on daily basis for weeks or months; occasionally shorter courses are sufficient. Patients should be given an adequate trial of prophylactic agents for at least two months, before it can be deemed a failure.