Christiane Ferran, MD,PhD

Staff PHD

Vascular Surgery

Medicine

Contact Information

Office:	RN-0370F
Phone:	617-667-0440
Fax:	617-667-0445
Email:	cferran@bidmc.harvard.edu
Address:	330 Brookline Ave; RN-0370F Boston, MA 02215

Advanced Degree And Training

Year	Institution	Area or Rank
1983	Saint Joseph University	Medicine (MD)
2000	BIDMC	Associate Professor

Research Lab Team Members

Vilmosne Csizmadia MSc

Claudio Silva PhD

Major Research Theme

The work in my laboratory is focused on the understanding of the function (s) of the anti-apoptotic genes A20, Bcl-2, Bcl-xL and A1 in different cell types, their relationship to the pathophysiology of diseases and their potential therapeutic use in organ transplantation, diabetes, atherosclerosis and hepatitis. This interest is based on our original finding that these genes serve a broad cytoprotective function in endothelial cells. Expression of A20, A1, Bcl-2 and Bcl-xL in endothelial cells not only protects the cells from apoptosis but also serve a broad anti-inflammatory purpose.

Publications

List of Publications via PubMed database at NIH NLM

External Recognition

1994       Invited Lecture on Xenotransplantation: potential issue beyond natural antibodies and complement in Strategies for successful xenotransplantation. IBC USA Conference. Washington D.C. USA.
1995       Invited Lecture on Xenotransplantation at the Pediatric Transplantation meeting University of Chicago, Northwestern, Illinois.
1996       Chairman at the XVI International Congress of Organ Transplantation, Barcelona, Spain.
1997       Invited Lecture on Xenotransplantation at the Annual Nephrology Meeting of Necker Hospital, Paris France.
1997       Chairman at the IV International Xenotransplantation Meeting, Nantes, France.
1997       Invited Lecture on the New Immunosuppressive Protocols in organ Transplantation and the Advances in Xenotransplantation at the 4th meeting of the Arab Society of Nephrology and Transplantation. Beirut, Lebanon.
1998       Invited lecture on Genetic Engineering in Transplantation at the annual Transplantation seminars of Nantes, France.
1998        Invited lecture on the State of the Art in Xenotransplantation at the Transplantation Grand Round of the University of Minneapolis, Minnesota.
1998       Invited Lecture on the Mechanisms of Delayed Xenograft Rejection. The Transplantation Club. Paris, France.
1998       Invited Lecture on Anti-apoptotic and ï¿½protectiveï¿½ genes in graft rejection and acceptance. The 31st Annual meeting of the American Society of Nephrology, November 1998, Philadelphia, PA.
1999 Invited Lecture to the Egyptian Society of Nephrology. on the topics of Xenotransplantation and the use of new immunosuppressive regimen in allotransplantation. Cairo, Egypt.
1999       Chairman at the Vth International Xenotransplantation Meeting October, Nagoya, Japan.
2000 Lecturer at a transplantation course organized by the Brazilian Society of Transplantation on the topics of vascular biology and transplantation and gene therapy in organ transplantation. March 21-24, Buzios, Brazil.
2000       Invited Lecturer at the 96th American Thoracic Society on the role of Bcl-2 genes in apoptosis, May 5-10 Toronto, Canada.
2000       Moderator of a Workshop on gene therapy in organ transplantation, at The Transplant 2000 meeting of the ASTS and AST, May 13-17, Chicago, IL, USA.
2000       Lecturer at the VIIth International congress of the Middle Eastern Society of Organ Transplantation on the topics of gene therapy in organ transplantation and xenotransplantation,. June 8-11, Beirut, Lebanon.
2000 Chairman at the XVIIIth International meeting of the Transplantation Society, August 27, Sep 1 2000, Rome Italy.
2000 Lecturer at the European Symposium for diabetes. August 11-14, Keble College. Oxford. United Kingdom. Protective genes in islet transplantation and autoimmunity.
2000        Lecturer at the Transplantation grandrounds on the topic of genetic engineering of organ transplant. October 2000, University of Cincinnati, OH.
2001 Lecturer at the Sixth International Conference on Tolerance Induction. Topic Gene therapy in tolerance induction. Tucson, Arizona, January 21-24, 2001.
2001 Chairman and Lecturer at Basic Science Symposium of the Transplantation Society. Protective Genes and Tolerance Induction. Thun, Switzerland, August 21-26, 2001.
2001 Invited speaker, at the VI congress of the International Xenotransplantation Association. Plenary session, topic: ï¿½Endothelial protective Strategiesï¿½. Chicago, Illinois. September 29-October 3, 2001.
2001 Invited speaker at the 2ND International Congress on Immunosuppresion. Plenary session, topic: ï¿½ Strategies to overcome chronic rejectionï¿½. San Diego, California. December 5-8, 2001.
2002       Invited lecturer at the Transplantation Grand Rounds, University of Pensylvania Medical Center, school of Medicine, Philadelphia, Pensylvania. Topic: ï¿½Protective strategies to overcome allograft rejectionï¿½. February 405 2002.
2002       Invited Speaker at annual meeting of the Royal Society of Medicine. Topic: Xenotransplantationï¿½. London, UK. March 20, 2002.
2002       Invited Speaker and chairman at the annual meeting of the Transplantation Society of Australia and New Zealand. Topic: ï¿½Protective strategies to overcome organ rejectionï¿½. Canberra, Australia. April 10-12th, 2002.
2002 Invited lecturer at the 2002 FASEB summer Research Conference on Transplantation Immunology. Topic: Endothelial cell cytoprotection in Transplantationï¿½. The Vermont Acadamy in Saxtons River, Vermont. Jume 15-2002.
2003        Invited speaker at the Transplantation grand round, Lahey clinic Worcester MA. A20 and Liver transplantation. February 2003.
2003 Annual Symposium in Vascular Surgery The Colonnade Hotel, Boston January 16, 2003.
2003        Seminars in Vascular Biology (March 16, 2003): Childrenï¿½s Hospital, Boston, MA. Help the EC live and let the SMC die.
2003 Invited lecturer at the Seventh International Xenotransplantation CongressGlasgow, September 30-October 4 2003. Protective genes in xenotransplantation.
2004              Invited lecturer at the MESOT (Middle Eastern Society for Organ Transplantation). Topic: Xenotransplantation: Sate of the art. Ankara, December 2004.
2005        Invited lecturer at the 5th Boston Basic Science Seminar in Vascular Surgery. The Colonnade Hotel, Boston, MA, USA. January 20th 2005. Title: Novel Therapeutic Leads to Prevent and Cure Intimal Hyperplasia.
2005       Invited lecturer at the Vascular Biology grand rounds. Brighamï¿½s and Women Hospital. Boston, MA. March 29th 2005. Title: A20 and atheroprotection.
2005       Invited lecturer at the 5th Beaune Seminar in Transplant Research. Beaune France. June 2nd and 3rd 2005. Title: Expression of Protective Genes in Endothelial Cells.
2005       Invited Lecturer at the IX Brazilian Congress of Organ Transplantation. July 1st to July 6th 2005 Bahia, Salvador, Brazil.

Major awards and committee assignments
Reviewer for Several peer review highly ranked journals including: Blood, Arteriosclerosis Thrombosis and Vascular Biology, Transplantation, Circulation, Journal of Immunology, American Journal of Rheumatology, American Journal of Transplantation, American Journal of Kidney Diseases, Nephrology Dialysis and Transplantation.
1999-2002 Scientific Reviewer for the Juvenile Diabetes Foundation International
2002 Mary Jane Kugel Award. Juvenile Diabetes Foundation International.
2004 Reviewer for the NIH/NIDDK. SRG: Pilot and Feasibility Program in Islet cell Biology
2005 Reviewer for the NIH/NIDDK Special emphasis panel: ZDK1 GRB-G. Ancillary studies to Adult Liver Transplantation Clinical Research.
2005-present: Member of the Scientific Advisory Counsil (SAC) of the Roche Organ Transplant Research Foundation (ROTRF).
2006       Reviewer for the World Transplant Congress (July 2006, Boston, MA, USA)
2006       Reviewer for the Boston Association in Diabetes and Endocrinology Research (BADERC).
2006       Reviewer for the NIH Study Section Tolerance, Transplantation and Tumor Immunology (TTT) (October 9-10, 2006)
2007       Reviewer for the NIH Study Section Tolerance, Transplantation and Tumor Immunology (TTT) (May 31-June 1, 2007)
2007       Reviewer for the American Transplant Congress 2008.
2008       Reviewer for the XXII International Congress of the Transplantation Society 2008.

Major Collaborative Activities

Collaborator with the Sleep apnea group at The Brigham and Women's hospital.
Member of the Transplant Center at BIDMC (Drs Strom, Hanto, Maki, Monaco, Li, Zheng, Robson and Bach)
Member of the Vascular Biology Research Center at BIDMC (director: W. Aird)
Co-director of the Harvard Longwood T32 training grant in Vascular Surgery (Dr. F. W. LoGerfo)

Investigator's Lab Web Site

Research Lab URL	None listed
Harvard Catalyst Site:	Ferran Harvard Catalyst Web Site