Jeffrey S Flier, MD
Research Student Intern
Research Operations
Contact Information
| Office: | |
| Phone: | 617-735-3343 |
| Email: | jflier@bidmc.harvard.edu |
| Address: | 330 Brookline Ave Boston, MA 02215 |
Advanced Degree And Training
| Year | Institution | Area or Rank |
| 1972 | Mt Sinai School of Medicine | MD |
| 1974 | Mt Sinai Hospital Internal Med | Resident |
| 1974 | NIH | Clinical Associate |
| 1978 | Beth Israel Hospital | Assistant Professor |
| 1982 | Beth Israel Hospital | Associate Professor |
| 1985 | Whitehead Institute | Visiting Scientist |
| 1993 | BIDMC | Professor |
Areas of Interest
| 2 Metabolic | 3 Neuroscience |
Major Research Theme
|
My laboratory has long been interested in the regulation and dysregulation of metabolism, with greatest emphasis on the systems regulating appetite, body weight, metabolic rate, and glucose and lipid metabolism. The primary diseases on which we focus are diabetes and obesity, but we are also interested in endocrine disease more broadly, especially neuroendocrine disease. We are especially interested now in the physiologic mechanisms by which peripheral signals communicate to the brain, and how the brain exerts influence over peripheral metabolic events. A major current interest that spans all of our concerns is the hormone leptin, which is a critical hormone, produced largely in fat tissue, that signals to the brain (and other sites). We have for many years been interested in the actions of insulin, and the mechanisms for insulin resistance. Over the years, our work has involved human studies, experimental animal models (including genetically modified mice), and in vitro studies using genetic and biochemical techniques. We utilize whatever techniques are suitable to the questions that excite our interest. Our central goal is to identify the pathways that regulate metabolism and body weight, to examine the role of these pathways in disease, and utilize these insights to develop novel therapeutic strategies |
Publications
External Recognition
| Elected Fellow, American Academy of Arts and Sciences Member, Institute of Medicine, National Academy of Sciences Solomon Berson Lecture, American Physiological Society Organizer - Keystone Conference on Obesity and Weight Regulation Eli Lilly Award, American Diabetes Association Banting Medal, American Diabetes Association Board of Consulting Editors, Science Associate Editor, Cell Metabolism |
Major Collaborative Activities
| Collaborative studies with the lab of Dr. Eleftheria Maratos-Flier of Joslin Diabetes Center on the role of Melanin Concentrating Hormone. |
Investigator's Lab Web Site
| Research Lab URL | None listed |
| Harvard Catalyst Site: | Flier Harvard Catalyst Web Site |
