Paula Fraenkel, MD
Non Paid Employee
Research Operations
Contact Information
| Phone: | 617-667-2168 |
| Fax: | 866-345-0065 |
| Address: | 330 Brookline Ave Boston, MA 02215 |
Advanced Degree And Training
| Year | Institution | Area or Rank |
| 1995 | Harvard Medical School | MD |
| 1995 | Tufts/New England Medical Center | Intern |
| 1996 | Tufts/New England Medical Center | Resident |
| 1998 | Beth Israel Deaconess Medical Center | Fellow |
Areas of Interest
| 1 Cancer | 2 Metabolic |
Major Research Theme
| Anemia affects 10% of Americans over age 65 and is associated with cognitive impairment, increased morbidity, and mortality. In 25% of these patients, anemia can be attributed to chronic inflammation, while in 33% the etiology has been unexplained. Inappropriately elevated levels of hepcidin, a transcriptionally regulated peptide hormone, have been proposed as the cause of anemia of chronic inflammation (ACI), while the causes of unexplained anemia (UA) are unknown. Due to their low cost and hematologic similarities to humans, we are utilizing the zebrafish as a model organism to identify small molecules and genes involved in the regulation of hepcidin expression and erythropoieisis. The goal of our research is to develop new treatment and prevention strategies for chronic anemia. |
Publications
External Recognition
| Howard Hughes Medical Institute Postdoctoral Fellowship; Amgen Fellowship; ASH Scholar Award; K08 grant: Genetic Analysis of Iron Homeostasis from NIDDK; oral presentations: First International Bioiron Society Meeting, Prague, Czech Republic, May 23-27, 2005; National Meeting of the Red Cell Club, Boston, MA, October 28, 2007; Annual Meeting of the American Society of Hematology, Atlanta, GA, December 10, 2007. |
Investigator's Lab Web Site
| Research Lab URL | None listed |
| Harvard Catalyst Site: | Fraenkel Harvard Catalyst Web Site |
