Steven D Freedman, MD,PhD
Staff Physician
Gastroenterology
Contact Information
| Office: | DA-0501 |
| Phone: | 617-667-5576 |
| Fax: | 617-667-0536 |
| Email: | sfreedma@bidmc.harvard.edu |
| Address: | 330 Brookline Ave; DA-0501
Boston, MA 02215 |
Research Lab Team Members
| Joanne Brown | Clementina Dimonda RN |
Major Research Theme
|
Chronic pancreatitis and cystic fibrosis. Our group is interested in the mechanism by which Cystic Fibrosis (CF) gene mutations lead to the phenotypic expression of disease. We have discovered that this involves alterations in fatty acid metabolism. Correction by high doses of docosahexaenoic acid in a mouse knockout model of CF reverses the pathology. Studies are underway in humans in CF and CF related diseases such as Primary Sclerosing Cholangitis and Pancreatitis. In addition, in collaboration with Alvaro Pascual-Leone MD, PhD in neurology, we have discovered that site within the brain (cortical SII) that modulates visceral pain sensation in patients with chronic pancreatitis. In an NIH funded study, we have shown that pain is attenuated in response to a 10 day course of repetitive Transcranial Magnetic Stimulation. |
Publications
External Recognition
| Recipient of the American Gastroenterological Association Industry Scholar Award 1999 North American Cystic Fibrosis Foundation Plenary Speech Co-Director, Havard Clinical/Translational Science Center (Associate Dean for Clinical and Translational Research) NIH grant council Cystic Fibrosis Grant council Canadian Cystic Fibrosis Grant council 1996 Patent granted on 7/29/97 on design and implementation of a modified secretin pancreatic function test (Patent# 5651769). 1998 Patent granted on 1/30/2001 (US patent # 6.180.671) on a novel lipid formulation for the treatment of conditions related to imbalances in Docosahexaenoic and Arachidonic Acid. |
Major Collaborative Activities
| Nid Afdhal at BIDMC Lap-Chee Tsui/Peter Durie at the Hospital for Sick Children in Toronto Brian O'Sullivan, UMASS Medical Center Alvaro Pascual-Leone at BIDMC |
Investigator's Lab Web Site
| Research Lab URL | None listed |
| Harvard Catalyst Site: | Freedman Harvard Catalyst Web Site |
