David J Friedman, MD
Principal Investigator
Nephrology
Contact Information
| Office: | RN-0227B |
| Phone: | 617-667-0253 |
| Fax: | |
| Email: | dfriedma@bidmc.harvard.edu |
| Address: | 330 Brookline Ave; RN-0227B
Boston, MA 02215 |
Advanced Degree And Training
| Year | Institution | Area or Rank |
| 2000 | Yale School of Medicine | MD |
| 2000 | BIDMC Internal Medicine | ABIM Board Certified |
| 2003 | BIDMC Nephrology (Clinical) | ABIM Board Certified |
| 2004 | BIDMC Nephrology (Research) | Instructor |
Areas of Interest
| 2 Metabolic |
Major Research Theme
|
My laboratory studies three main topics: 1) Renal microvascular disease, particularly diabetic nephropathy. 2) Renovascular autoregulation 3) Venous arterialization, with applications to arteriovenous fistula maturation and stenosis. The common theme linking these three topics is an interest in the puringeric signaling system. This system is composed of purinergic receptors (P2X and P2Y), adenosine receptors, and the ectonucleotidases that regulate extracellular purine levels. Purinergic signaling is important in many cellular processes including inflammation, thrombosis, apoptosis, cell growth, and blood vessel tone. We use knock-out and transgenic mice for various components of this system to investigate their roles in normal physiology and disease models. In addition, along with collaborators at the Broad Institute and Wake Forest School of Medicine, we test human variation in these genes to study their role in human disease. |
Publications
Investigator's Lab Web Site
| Research Lab URL | None listed |
| Harvard Catalyst Site: | Friedman Harvard Catalyst Web Site |
