My laboratory is focused on the study of vascular biology. Specifically, we are interested in understanding how endothelial cell phenotypes are differentially regulated in space and time. To that end, we use a variety of in vitro and in vivo model systems to study endothelial cell-type specific signaling networks and gene expression.
Tsai C, Zhang J, Minami T, Voland C, Zhao S, Yi X, Lassalle P, Oettgen P, and Aird WC. Cloning and characterization of the human lung endothelial cell-specific molecule-1 promoter. J Vasc Res 2002;39:148-159
Minami T, and Aird WC. Thrombin Stimulation of the VCAM-1 Promoter in Endothelial Cells is Mediated by Tandem NF-kB and GATA Motifs. J Biol Chem 2001;276;47632-47641.
Tsai JC, Liu L, Zhang J, Spokes KC, Topper TN, Aird WC. Epidermal Growth factor induces Egr-1 promoter activity in hepatocytes in vitro and in vivo. Am J Physiol Gastrointest Liver Physiol 2001;281:G1271-1278
Minami T, Rosenberg RD, Aird WC. TGF-b-1-mediated inhibition of the Flk-1/KDR is mediated by a 5�UTR palindromic GATA site. J Biol Chem 2001;276:5395-5402.
External Recognition:
Invited Presentations
2000
Invited Speaker, Royal College of Surgeons in Ireland, Dublin, Ireland;
Invited Speaker, Vascular Biology Working Group US Chapter, Newport Beach, California;
Invited Speaker, 96th International Conference, American Thoracic Society, Toronto, Canada;
Keynote Speaker, American Heart Association First Conference on Arteriosclerosis, Thrombosis and Vascular Biology, Denver, Colorado; Program Moderator, American Heart Association First Conference on Arteriosclerosis, Thrombosis and Vascular Biology, Denver, Colorado;
Invited Speaker, Cancer Biology Seminar Series, Beth Israel Deaconess Medical Center, Boston, Massachusetts; Co-Chairman and Invited Speaker, NHLBI workshop on Endothelial Cell Phenotypes in Heart, Lung and Blood Diseases, Bethesda, Maryland;
Invited Speaker, Cardiovascular Research Seminar Series, St. Elizabeth�s Medical Center, Tufts University School of Medicine, Boston, Massachusetts;
Invited Speaker, Work-in-Progress Seminar, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma;
Invited Speaker, Margaux Conference on Critical Illness, Margaux, France;
Chairman and Invited Speaker, American Heart Association 73rd Scientific Sessions, New Orleans, Louisiana;
Invited Speaker, Interdisciplinary Seminar Series and Thrombosis/Vascular Biology Series, Institute for Medicine and Engineering, University of Pennsylvania, Pennsylvania.
2001
Invited Speaker, American Heart Association, Scientific Conference on Therapeutic Angiogenesis and Myocardial Laser Revascularization, Santa Fe, New Mexico;
Invited Speaker, Society of Critical Care Medicine, 30th International Educational and Scientific Symposium, San Francisco, California;
Invited Speaker, Clinicopathological Conference, Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts;
Invited speaker, Vascular Biology Affinity Group Seminar Series, The Scripps Research Institute, La Jolla, California;
Invited Speaker, Hematology Lecture Series, Princess Margaret Hospital, University of Toronto, Canada;
Invited Speaker, Medical Grand Rounds, St. Michael�s Hospital, University of Toronto, Canada;
Invited Speaker, Gordon Research Conference, Illicit Substance Detection: Chemical/Biological Agents, Mount Holyoke College, South Hadley, Massachusetts;
Chairman and Invited Speaker, Satellite Symposium, American Society of Hematology, Orlando, Florida;
Invited Speaker, Research Day, Beth Israel Deaconess Medical Center, Boston, Massachusetts;
Invited Speaker, Plenary Lecture, Margaux III Conference on Critical Illness, Sedona, Arizona;
Invited Speaker, Cardiology Grand Rounds, Boston Medical Center, Boston University, Boston, Massachusetts.
2002
Invited Speaker, Hematology/Oncology Grand Rounds, University of Chicago Medical Center, The University of Chicago, Chicago, Illinois;
Invited Speaker, Society of Critical Care Medicine, 31st International Educational and Scientific Symposium, San Diego, California;
Invited Speaker, Medical Grand Rounds, The Jewish Hospital, University of Cincinnati, Cincinnati, Ohio;
Invited Speaker, Medical Grand Rounds, Beth Israel Deaconess Medical Center, Boston, Massachusetts; Invited Speaker, Hepatic Vascular Diseases; American Association for the Study of Liver Diseases, Atlanta, Georgia;
Invited speaker, Plenary Lecture, 22nd International Symposium of Intensive Care and Emergency Medicine, Brussels, Belgium; Invited Speaker, Cancer Biology Seminar Series, BIDMC, Boston, Massachusetts;
Invited Speaker, Division of Neoplastic Diseases & Related Disorders, Medical College of Wisconsin, Milwaukee, Wisconsin.
Awards
1998-1999, Junior Investigator Award, Beth Israel Deaconess Medical Center;
1999-2001, American Society of Hematology Scholar Award;
2001-2002, Enterprise Award, Beth Israel Deaconess Medical Center.
Senior Editor, Physiological Genomics
Ad Hoc Member, Experimental Cardiovascular Sciences Study Section, National Institutes of Health
Major Collaborative Activities:
SCOR Program with Drs. Simons, Rosenberg and Laham
Joint lab meetings with Peter Oettgen
