My laboratory investigates the cell biology of inflammation, with emphasis on leukocyte-endothelial interactions, through development and application of novel and dynamic fluorescence imaging techniques.
Carman CV, Sage PT, Sciuto TE, de la Fuente MA, Geha RS, Ochs HD, Dvorak HF, Dvorak AM, Springer TA. (2007) Trans-cellular diapedesis is initiated by leukocyte podosomes. Immunity 26: 784-97. Highlighted – Immunity Previews: Immunity 26: 753-5.
Carman CV and Springer TA. (2004) A Transmigratory cup in leukocyte diapedesis both through individual vascular endothelial cells and between them. J Cell Biol 167: 377-88. Highlighted - In This Issue: J Cell Biol 167: 189.
*Kim M, *Carman CV and Springer TA. 2003. Bidirectional transmembrane signaling by cytoplasmic domain separation in integrins. Science 301: 1720-25. *Co-first authors. Highlighted – This week in Science: Science. 301: 1625.
Carman CV, Jun C-D, Salas A and Springer TA. 2003. Endothelial cells proactively form microvilli-like membrane projections upon intercellular adhesion molecule 1 engagement of leukocyte LFA-1. J Immunol 171: 6135-44.
External Recognition:
1999 Sigma Xi Student Research Award
1999-2008 Ad hoc reviewer, Journal of Biochemistry
2000 Thomas Jefferson University Alumni Outstanding Thesis Prize
2000-2002 American Heart Association Postdoctoral Fellowship
2000-2008 Ad hoc reviewer, Biochemistry
2003-2005 NRSA Fellow, Postdoctoral Training Program in Cancer Immunology, DFCI
2003-2008 Ad hoc reviewer, Journal of Immunology
2005-2009 Arthritis Investigator Award Research Grant, Arthritis Foundation
2005-2008 Ad hoc reviewer, Journal of Cell Biology
2006-2008 Ad hoc reviewer, Molecular Biology of the Cell
2006-present Center for Vascular Biology Research Planning Committee, Member
2006-present Center for Vascular Biology Research Website Committee, Chair
2007-2008 Ad hoc reviewer, Blood
2007 Federation of Clinical Immunology Societies (FOCIS)-Center of Excellence, Member
2007-present Harvard Immunology Resource Committee
2007-2008 Ad hoc reviewer, Nature
2007-2008 Ad hoc reviewer, American Journal of Physiology: Cell Physiology
2007 Harvard Medical School, Human Physiol. & Pathophysiol. DMS220, Lecturer
2007-2008 Harvard Medical School, Immunology 202, Lecturer
2008 Ad hoc reviewer, Journal of Thrombosis and Haemostasis
2008 Ad hoc reviewer, Journal of Reproductive Immunology
2008 Ad hoc reviewer, The Anatomical Record
Major Collaborative Activities:
I work with both Dr. Ann Dvorak and Dr. Harold Dvorak in the Pathology Department of BIDMC to study the ultrastructure of leukocyte-endothelial interactions both in vitro and in vivo. I work with Dr. Laura Benjamin, also in the Pathology Department at BIDMC, to develop in situ/in vivo imaging of inflammation. With Dr. Motomu Shimaoka at the CBR Institute for Biomedical Research, HMS I am developing novel targeted delivery approaches.
