characterise HIV and human Cytomegalovirus genes which cause resistance to antiviral drugs
Conduct clinical tlrials of antiviral drugs or therapeutic vaccines against HIV-
Study pathogenesis of HIV and HCMV in human disease and the role of HCMV in cardiiovascular disease
Develop assays to measure viral burden in human tissues and determine antiviral susceptlibillity.
Study the role of HCMV in inducing vascular injury and in inducing human gene expression which contributes to vascular injury
Study the role of MCMV in a murine model of hypertensilon
Weinberg,Jabs,Chou, Martin,Lurain,Forman, Crumpacker Mutaions conferring foscarnet resistance in a cohort of patients with
acquired immunodificiency syndrome and comegelovirus retinitis, J. Infect. Dis 2003 187 777-784
Zhang,Attar, Cohen, Crumpacker, Scadden, Silencing p21WAF1/CIP1/SD1 expression induces gene transductiion efficiency
in primary hematopoetic cells,Gene Therapy 2005, May AOP
Zhang and Crumpacker HIV-1 RNA in peripheral blood mononuclear cells of patients receiving highly active antiviral therapy,J. Infect. Dis 2001 184 1341-1344
Crumpacker and Schaffer, New anti-HSV therapeutics target the Hellicase -primase complex. Nature Medicine 8 327-328, 2002
Zhang and Crumpacker HIV-1 nucleocapsid protein nuclear localization mediates early viral mRNA expression, J. Virol. 2002
76 10444-10454
External Recognition:
Jornal of Virology, Editorial Board, 1999-2004
Executive Committee, Division of AIDS , Harvard Medical School 2001-2007
Jorn. of Virology,Assoc Editor 1994-2004
Harvard Med. School Div of Aids Exec. Comm. 2001-2007
Am. Microbiology Society Lectureship Award for Herpesvirus Chemotherapy.1986
Governor's Recognition Award for Contributions to AIDS Research, 1986
NIH Basic Science Study Section-AIDS, 2005
Course director HST 040 Micorbiial Pathogenesis, 1994-2005
Major Collaborative Activities:
Bruce Dezube, Div of Hem-ONC, BIDMC
Martin Hirsch, Mas Gen Hosp.
Joseph Sodroski, Dana Farber Cancer Institurte, HMS
Raphael Dolin, Div. of AIDS, HMS
