1. Molecular mechanisms of T cell tolerance.
2. The role of p27kip1 in T helper and cytolytic responses.
3. Regulation of T cell immune responses by Rap1.
4. PI3K and its downstream pathways as therapeutic targets for T-ALL.
5. Reconstitution of T cell immunity after unrelated cord blood transplantation in patients with hematologic malignancies.
1. Lafuente EM, van Puijenbroek AAFL, Krauss M, Carman CV, Constantine E, Freeman GJ, Berezovskaya A, Springer TA, Gertler FB, Boussiotis VA. RIAM, an Ena/VASP and Profilin ligand interacts with Rap1-GTP, and mediates Rap1-induced adhesion. Developmental Cell 2004; 7: 585-595.
2. Appleman LJ, Chernova I, Li L, Boussiotis VA. CD28 costimulation mediates transcription of SKP2 and CKS1, the substrate recognition components of SCFskp2 ubiquitin ligase that leads p27kip1 to degradation. Cell Cycle 2006; 5:2123-2129.
3. Li L, Iwamoto Y, Berezovskaya A, Boussiotis VA. A pathway regulated by the cell cycle inhibitor p27 and the checkpoint inhibitor Smad3 is involved in induction of T cell tolerance. Nature Immunol. 2006; 7(11): 1157-65.
4. Tzachanis D*, Li L*, Lafuente EM, Berezovskaya A, Freeman GF, Boussiotis VA (*first co-authors). Twisted Gastrulation (Tsg) is regulated by Tob and enhances TGF-b signaling in T lymphocytes. (* first co-authors). Blood 2007; 109: 2944-2952.
5. Brown J and Boussiotis VA. Umbilical cord blood transplantation: Basic biology and clinical challenges to immune reconstitution. Clinical Immunol. 2008; PMID: 18395491 Epub April 3, 2008.
External Recognition:
Invited presentations and committee assignments 2007-2008 academic year
2nd International Symposium on Immune Surveillance, Tokyo, Japan
Dana-Farber/HCC Program in Cancer Immunology
Institute of Molecular Medicine, University of Lisbon Medical School, Portugal
Hematology-Oncology Grant Rounds, Beth Israel Deaconess Medical Center
Transfusion Medicine Grant Rounds, Brigham and Women’s Hospital
Annual Meeting of the Hellenic Society of Hematology
13th World Congress on Advances in Oncology and Molecular Medicine
Committee assignments
Regular member, Cancer Immunology and Immunotherapy Study Section, NCI/NIH
Ad hoc member, Scientific Committee, National Science Foundation
Scientific Committee, European Commission Grants
Scientific Committee, Dutch Cancer Society Foundation
Scientific Committee, UK Cancer Research Funding
Major Collaborative Activities:
Gordon J. Freeman, Dana-Farber Cancer Institute
Anjana Rao, Center for Blood Research
Arlene H. Sharpe, Harvard Medical School
Karen Ballen, Massachusetts General Hospital
Joseph Antin, Dana-Farber Cancer Institute
Jerome Ritz, Dana-Farber Cancer Institute
