I am interested in central nervous system regulation of sleep, respiration, and sleep apnea. Current projects address state-dependent changes in upper airway muscle activity that cause obstructive sleep apnea and central mechanisms of general anesthesia.
Eikermann M, Fassbender P, Malhotra A, Jordan AS, Zaremba S, Gautam S, White DP, Chamberlin NL (2008). Differential effects of isoflurane and propofol on genioglossus muscle function and breathing Anesthesiology, 108(5), 897-906.
Chamberlin NL, Eikermann M, Fassbender P, White DP, Malhotra A (2007). Genioglossus Premotoneurons and the Negative Pressure Reflex in Rats J Physiol, 579, 515-26.
Eikermann M, Zaremba S, Malhotra A, Jordan AS, Rosow C, Chamberlin NL.
Neostigmine but not sugammadex impairs upper airway dilator muscle activity and breathing.
Br J Anaesth. 2008 Jun 16. Epub ahead of print
Chamberlin NL (2004). Functional organization of the parabrachial complex and intertrigeminal region in the control of breathing Resp Physiol and Neurobiol, 143, 115-125
Chamberlin, N. L., Arrigoni, E. Chou, T. Scammell, T. E. Greene, R.W. and Saper C. B. (2003) Effects of adenosine on GABAergic synaptic inputs to identified ventrolateral preoptic neurons Neuroscience, 119, 913-918.
Major Collaborative Activities:
I collaborate with Dr. Atul Malhotra at the Brigham and Women's Hospital, Matthias Eikermann at the Mass. General Hospital, and Drs. Jun Lu, Clif Saper, and Elda Arrigone at BIDMC.
