Our research is conducted under the auspices of the Margret and H.A. Rey Institute for Nonlinear Dynamics in Physiology and Medicine, and the NIH Research Resource for Complex Physiologic Signals (www.physionet.org). The work is devoted to making databases and software available to other researchers and to basic research in the analysis of complex signals to extract information with relevance to basic mechanisms and bedside diagnostics. The research is highly interdisciplinary and involves the interactions of physiologists, clinicians, physicists, and bioengineers. A major theme of the work is understanding the complex, fractal/nonlinear variability in the healthy function of many different integrative feedback systems and the breakdown of this complexity with aging and disease.
1) Goldberger, A.L et al. Fractal dynamics in physiology: alterations with disease and aging. Proc Natl Acad Sci (USA) 2002 (Suppl 1): 99:2466-2472.
2) Goldberger, A.L. Clinical Electrocardiography: A Simplified Approach. Edition 7. St. Louis, Mosby/Elsevier, 2006.
3) Costa M, Goldberger AL, Peng CK. Multiscale entropy analysis of biological signals. Phys Rev E 2005:71:021906.
4) Amaral LAN, Diaz-Guilera A, Moreira A, Goldberger AL, Lipsitz LA. Emergence of complex dynamics in a simple model of signaling networks. Proc Natl Acad Sci USA 2004;101:15551-15555.
5) Thomas RJ, Mietus JE, Peng CK, Goldberger AL. An ECG-based technique to assess cardiopulmonary coupling during sleep. Sleep 2005:28;1151-1161.
External Recognition:
S.Robert Stone Teaching Award (Beth Israel Hospital/Harvard Medical School)--1988; Burgess Memorial Lectureship (Brown University Medical School)--1996; Roland D. Pinckham, MD Basic Science Lectureship (Swedish Medical Center, Seattle)--1998; AOA Honor Lectureship University of South Florida, College of Medicine--2002; Harvard University Provost's Fund Award for Innovation in Instructional Technology (2002); Harvard University Provost's Fund Award for Innovation in Instructional Technology (2002); Carle Foundation Hospital, Gianturco Lectureship (Foundation Day, 2003), University of Illinois College of Medicine at Urbana Champaign; Giles F. Filley Lecturer, Thomas L. Petty Aspen Lung Conference, 48th Annual Meeting (2005); Visiting Professor, Wake Forest University School of Mediciine, 2006; Advisory Group Member, NHLBI Working Group on Bioinformatics and Computational Biology, July, 2006; Plenary Speaker, NIH Knowledge Environments for Biomedical Research (KEBR), Bethesda MD, 2006.
Research is currently supported by grants from the NIH/National Center for Research Resources and the Mathers Charitable Foundation with Dr. Goldberger as PI, and by a grant from the James S. McDonnell Foundation with Dr. Goldberger as co-investigator.
Major Collaborative Activities:
Collaborators include Dr. Robert Thomas, Dr. Janet Mullington, Dr. Alvaro Pascual-Leone, Dr. Steven Freedman (GCRC), Dr. Lewis Lipsitz (Gerontology), Dr. Donald Schomer (Neurology), Dr. Vera Novak (Gerontology), Dr. Christos Mantzoros (Endocrinology), as well as Dr. Steven Shea (Brigham and Women's Hospital).
