The major areas of investigation are: endothelial cell signaling, particularly lymphatic endothelium; interactions between hepatitis C and HIV envelope proteins; the role of HIV tat in cell signaling; the pathogenesis of hematopoietic progenitor cell apoptosis in HIV infected hosts; isolation and characterization of adult hematopoietic stem cells; role of cannabinoids in immunology. In addition, we are exploring new drugs for lymphoma.
Balasubramania A, Ganju RK, Groopman JE. Hepatitis C virus and HIV envelope proteins collaboratively mediate interleukin-8 secretion through activation of p38 MAP kinase and SHP2 in hepatocytes. J Biol Chem. 2003;278:35755-35766.
Munsh N, Balasubramanian A, Koziel M, Ganju RK, Groopman JE. Hepatitis C and human immunodeficiency virus envelope proteins cooperatively induce hepatocytic apoptosis via an innocent bystander mechanism. J Infect Dis. 2003;188:1192-1204.
Wang JF, Zhang X, Groopman JE. Activation of vascular endothelial growth factor receptor-3 and its downstream signaling promote cell survival under oxidative stress. J Biol Chem. 2004;279:27088-27097.
Zhang X, Groopman JE, Wang JF. Extracellular matrix regulates endothelial functions through interaction of VEGFR-3 and integrin alpha-5-beta-1. J Cell Physiol. 2005;202:205-214.
Zhang X, Wang JF, Chandran B, Persaud K, Pytowski B, Fingeroth J, Groopman JE. KSHV activation of VEGFR-3 alters endothelial function and enhances infection. J Biol Chem. 2005;280:26216-26224.
External Recognition:
Associate Editor: Blood
Member, Institute of Medicine/National Academy of Sciences
Major Collaborative Activities:
Collaboration with Dr. Margaret Koziel on hepatitis C biology
