Our research has focused on the reciprocal interactions between the brain and the reproductive endocrine system in neurological and neuropsychiatric disorders. Clinical investigations assess 1) the role of temporolimbic dysfunction on reproductive endocrine function and reproductive disorders in both men and women with epilepsy, 2)the role reproductive steroids in the pathophysiology and treatment of epilepsy and emotional disorders.
14. Herzog AG, Seibel MM, Schomer DL, Vaitukaitis JL, Geschwind N. Reproductive endocrine disorders in women with partial seizures of temporal lobe origin. Arch Neurol 1986; 43:341-346.
15. Herzog AG, Seibel MM, Schomer DL, Vaitukaitis JL, Geschwind N. Reproductive endocrine disorders in men with partial seizures of temporal lobe origin. Arch Neurol 1986; 43:347-350.
48. Herzog AG, Klein P, Ransil BJ. Three patterns of catamenial epilepsy. Epilepsia 1997; 38:1082-1088.
43. Herzog AG. Progesterone therapy in women with complex partial and secondary generalized seizures. Neurol 1995; 45:1660-1662.
76. Herzog AG. Reproductive endocrine regulation in men with epilepsy: effects on reproductive function and neuronal excitability. Ann Neurol 2002;51:539-542.
External Recognition:
1997-Member of Professional Advisory Board (National), Epilepsy Foundation of America
1999-Dorfman Award for one of the three top publications in psychosomatic medicine, Academy of Psychosomatic Medicine
2000-Nomination for ASPET award in experimental therapeutics and pharmacology, American Society for Pharmacology and Experimental Therapeutics
2001-Chairman of international conference that was responsible for the preparation of a consensus paper on the reproductive endocrine evaluation of women with epilepsy held in Bonn, Germany
2002-Featured speaker at the Latin American Epilepsy Congress held in Foz do Iguacu
2002-Member of the Scientific Program Committee, American Epilepsy Society
2003-Member, Research Infrastructure Subcommittee, American Epilepsy Society
2004-Chairman, Neuroendocrinology Section, American Academy of Neurology
Major Collaborative Activities:
1. Collaboration with Donald Schomer (BIDMC) and Edward Bromfield (BWH) in NIH and pharmaceutical clinical trials to determine the role of neuroactive steroids in the treatment of women and men with epilepsy
2. Collaboration with Alvaro Pascuale-Leone (BIDMC) to develop a non invasive transcranial magnetic stimulation method to asess the variation of cortical excitability in women with epilepsy during the menstrual cycle and the impact of neuroactive steroid treatments
