Beth Israel Deaconess Medical Center 330 Brookline Ave
Boston, MA 02215
Advanced Degree And Training Info:
Year
Institution
Area or Rank
1989
University of Pennsylvania
Medicine
1989
University of Pennsylvania
Medicine Resident
1992
Brigham and Womens Hospital
Renal Fellow
1996
Brigham and Womens Hospital
Instructor
2000
UMass Memorial Medical Center
Assistant Professor
2003
UMass Memorial Medical Center
Associate Professor
2005
Beth Isael Deaconess Medical Center
Assistant Professor
Research Team Listing
No team members listed
Areas of Interest:
Immunology, Transplantation
Major Research Theme:
I have focused on a number of clinical research themes related to renal transplantation. One is improving the process of evaluating potential living kidney donors. We continue to survey US transplant programs to document current practices in the hope of improving care. We also have a number of ongoing studies related to immunosuppressive protocols, including the appropriate use of IL2 receptor antibodies, siroliumus, anti-thymocyte globulin and novel immunosuppressive agents. I am also collaborating with members of the BIDMC radiology department as well as biotechnology companies to develop novel methods of measuring kidney function. I plan to apply these techniques to potential as well as past living kidney donors, renal transplant recipients and patients with chronic kidney disease
Patlolla V, Zhong X, Reed G, Mandelbrot DA. Efficacy of anti-IL-2 receptor antibodies compared to no induction and to antilymphocyte antibodies in renal transplantation. Am J Transplant 2007;7:1832-1841.
Mandelbrot DA, Pavlakis M, Danovitch GM, Johnson SR, Karp SJ, Khwaja K, Hanto DW, Rodrigue JR. The Medical Evaluation of Living Kidney Donors: A Survey of US Transplant Centers. Am J Transplant 2007;7:2333-43.
Rodrigue JR, Pavlakis M, Danovitch GM, Johnson SR, Karp SJ, Khwaja K, Hanto DW, Mandelbrot DA. Evaluating Living Kidney Donors:Relationship Types, Psychosocial Criteria, and Consent Processes at Transplant Programs in the United States. Am J Transplant 2007;7:2326-32.
Mandelbrot DA, Dhaliwal SK, Norfolk ER, Licho R, Reinhardt CP, Jaffry S. Validation of Neutron Activation as a Novel Method to Determine GFR. Nephron Clin Pract 2007;107:117-122
Mandelbrot DA, Oosterwegel MA, Shimizu K, Mitchell RN, Sayegh MH, Sharpe AH. B7 dependent costimulation in mice lacking CD28 and CTLA4. J Clin Invest 2001;107:881-7.
External Recognition:
American Society of Transplantation, Clinical Research Advisory Council
American Society of Transplantation, Chair, Healthy Donor Website Workgroup
American Society of Nephrology, Transplant Advisory Group
