To identify and understand the mechanisms that regulate T cell activation, T cell apoptosis, and T cell tolerance and to develop therapeutic strategies that can create stable tolerance to organ transplants.
Li XC, Demirci G, Ferrari-Lacraz S, Groves C, Coyle, A, Malek TR, Strom TB. IL-15 and IL-2: A matter of life and death for T cells in vivo. Nature Medicine 2001; 7: 114-118
Yu G, Xu X, Vu MD, Kilpatrick ED, Li XC. NK cells promote transplant tolerance by killing donor antigen presenting cells. Journal of Experimental Medicine 2006; 203: 1851-1858
Zhao Y and Li XC. Transplant tolerance: is it really free of concerns. Trends in Immunology 2007; 28: 376-377
Vu MD, Xiao X, Gao W, Degauque N, Chen M, Kroemer A, Killeen N, Ishii N, Li XC. OX40 costimulation turns off Foxp3 Tregs. Blood 2007; 110: 2501-2510
Kroemer A, Xiao X, Degauque N, Edtinger K, Wei HM, Demirci G, Li XC. The innate NK cells, allograft rejection, and a key role for IL-15. Journal of Immunology 2008; 180: 7818-7826
External Recognition:
2002 Weyth Basic Science Investigator Award, American Society of Transplantation.
2005-2008 Member, Basic Science Committee, American Society of Transplantation
Co-Chair, Abstract Review Committee on basic science, American Transplant Congress, May 20-25, 2005, Seattle, WA.
Chair, New Insights in Regulatory T cells in Transplantation session, American Transplant Congress, May 20-25, 2005, Seattle, WA.
Nov 11, 2002. Division of Nephrology, Cornell University Medical Center, New York, NY. Life and death of T cells: why should we care in transplantation?
June 30, 2005. 3rd World Congress of Nephrology, Singapore. T cell apoptosis-implications in immune response to alloantigens.
2008, AST/Weyth Achivement Award, American Society of Transplantation
Major Collaborative Activities:
Terry Strom on T cell tolerance
Mo Sayegh on T cell costimulation
Fritz Bach on HO-1 and cytoprotection
Takashi Maki on chimerism and tolerance
