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BIDMC Research Investigator / Faculty Information

Fritz H Bach MD

Surgery

Contact Information:

Title:	Staff PhD
Office:	RN-370D
Phone:	632-1199
Fax:	617-632-1198
Email:	fhbach@bidmc.harvard.edu
Address:	Beth Israel Deaconess Medical Center 330 Brookline Ave; RN-370D Boston, MA 02215

Advanced Degree And Training Info:

Year

Institution

Area or Rank

No data available

Research Team Listing

Fredy Rocuts MD

Michael Thomas MD

Hongjun Wang PhD

Barbara Wegiel PhD

Areas of Interest:

Immunology, Transplantation

Patient Oriented / Translational

Major Research Theme:

A.Demonstrate that HO-1 expression in organs or in islets will prolong survival of tthe organ/islets after transplantation.

B.Determine which product of HO-1 action on heme will mimic the results of HO-1 expression.

C.Test whether combined use of two products, such as carbon monoxide plus bilirubin, will show an additive or synergistic protective effect.

D.Study the interrelationship of nitric oxide and carbon monoxide.

Select Major Publications: List of Publications via PubMed database at NIH NLM

	Sato, Koichiro, Jozsef Balla, Neal Smith, Sophie Brouard, Leo Otterbein, Yuan Lin, Eva Csizmadia, Josef Anrather, Jean Sevigny, Simon C. Robson, Gregory Vercellotti, Augustine M. Choi, Fritz H. Bach, and Miguel P. Soares. Carbon Monoxide (CO) Generated by Heme Oxygenase-1 (HO-1) Can Prevent Xenograft Rejection.
	S. Brouard, L. Otterbein, J. Anrather, E. Tobiasch, F. H. Bach, A.M.K. Choi and M.P. Soares. Carbon monoxide generated by heme oxygenase-1 suppresses endothelial cell apoptosis. J. Exp. Med, 2000, 192 (7):1015-1025.
	Edda Tobiasch, Lukas Gunther, and Fritz H. Bach. HO-1 protects pancreatic b-cells from apoptosis caused by various stimuli. Journal of Investigative Medicine.
	Lukas G�nther, Pascal O. Berberat, Manabu Haga, Sophie Brouard, R. Neal Smith, Miguel P. Soares, Fritz H. Bach & Edda M. Tobiasch. Carbon Monoxide Protects Pancreatic b-cells from Apoptosis and Improves Islet Function/Survival after Transplantation. Diabetes, 51, April 2002.
	Soares P. Miguel, Brouard Sophie, Smith R. Neal, Bach H. Fritz. Heme oxygenase-1, a protective gene that prevents the rejection of transplanted organs. Immunological Reviews, Vol.184: 275-285.

External Recognition:

American Society for Clinical Investigation;
American Association of Immunologists;
Transplantation Society;
Established Investigator of the American Heart Association;
Modern Medicine, Distinguished Achievement Award, l974;
Sumner Memorial Lecturer; Recipient of the Peter Medawar Award 1998
Milwaukee Academy of Medicine, Distinguished Achievement Award, l977;
Leukemia Society of America, Natl. Board of Trustees, l979-l984;
American Red Cross, Distinguished Scientist Award, 1983;
Coll�ge de France (Professeur �tranger), 1984;
Weizmann Institute, International Board of Governors, 1985;
Foreign Member, Royal Dutch Academy of Sciences, 1987;
Emilio Trabucchi Foundation Award, 1989;
Charter Member, International Bone Marrow Transplant Registry, 1989;
Honorary Member, American Society of Transplant Surgeons 1991;
Honorary Member, Society of Cell Transplantation, 1994,
Peter Medawar Prize, International Transplantation Society, 1998.
Lewis Thomas Distinguished Professor/ChairHarvard Medical School 1997
Honorary Degree (M.D. honoris causa), Vienna Medical University, 2005

Major Collaborative Activities:

JDF International/HMS
BI Deaconess Medical Center B (Bach, F.H.) Administrative Operating Account

Investigator's Web Site:

Harvard Catalyst Site:

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