My research interests center on mammalian brain development, and in specific on the complex genetic factors that play a role in shaping the architecture of the brain. One area of concentration has been on the investigation of animal models for some of the differences that have been noted between the brains of dyslexics and those of normal readers. Another area of interest centers on the genetics of complex neuroanatomic traits in the mouse brain.
Rosen GD, Williams RW. Complex trait analysis of the mouse striatum: independent QTLs modulate volume and neuron number. BMC Neurosci 2001;2:5
Rosen GD, La Porte NT, Diechtiareff B, Pung CJ, Nissanov J, Gustafson C, Bertrand L, Gefen S, Fan Y, Tretiak OJ, Manly KF, Park MR, Williams AG, Connolly MT, Capra JA, Williams RW. Informatics center for mouse genomics: the dissection of complex traits of the nervous system. Neuroinformatics. 2003;1(4):327-42.
Galaburda AM, Loturco J, Ramus F, Fitch RH, Rosen GD. From genes to behavior in developmental dyslexia. Nat Neurosci. 2006;9(10):1213-7.
Rosen GD, Bai J, Wang Y, Fiondella CG, Threlkeld SW, LoTurco JJ, Galaburda AM. Disruption of neuronal migration by RNAi of Dyx1c1 results in neocortical and hippocampal malformations. Cereb. Cortex. 2007; 17:2562-2572.
Burbridge TJ, Wang Y, Volz AJ, Peschansky VJ, Lisann L, Galaburda AM, LoTurco JJ, Rosen GD. Postnatal analysis of the effect of embryonic knockdown and overexpression of candidate dyslexia susceptibility gene Dcdc2. Neuroscience. 2008;152(3):723–733.
External Recognition:
National Dyslexia Research Foundation Distinguished Young Investigator Award
Corresponding and Scientific Member, Academia Rodinensis Pro Remediatione
Major Collaborative Activities:
MRI examination of brains with malformation with Deborah Burstein, Radiology
