Beth Israel Deaconess Medical Center 330 Brookline Ave; RA-430A
Boston, MA 02215
Advanced Degree And Training Info:
Year
Institution
Area or Rank
1968
SUNY Downstate College of Medicine summa
Medicine
1968
Yale-New Haven Hospital
Resident
1970
National Cancer Institute
Clinical Associate
1973
Washington University
Fellow Hematology-Oncolog
1974
Harvard Medical School Beth Israel Hospital
Professor
Research Team Listing
No team members listed
Areas of Interest:
Cancer & Hematologic
Major Research Theme:
1. Genomic instability: we have developed a model system with which to identify the emergence of DNA rearrangements that follow exposure to a specific stimulus, e.g., exposure to a viral oncoprotein such as the AdE1A, or polyoma middle T antigens. We have established that these oncoproteins are necessary but not sufficient for induction of DNA rearrangements. Differential display analyses demonstrated the presence of several unique cDNAs the expression of which is upregulated, which are homologues of known helicases and appear to have an important role in generating a rearrangement event. 2. Another focus of research is clinical investigations evaluating novel therapies, be they biologicals or chemotherapy based as attempts at improvng therapy of solid tumors. 3. Lastly, I have developed an interest in ethical issues involved in clinical research and cancer care.
Ng SW, Eder JP, Schnipper LE, Chan VT. Molecular cloning and characterization of the promoter for the Chinese hamster DNA topoisomerase II alpha gene. J Biol Chem 1995 Oct 27; 270(43):25850-8
PMID: 7592770
Pentz RD, Joffe S, Emanuel EJ, Schnipper LE, Haskell CM, Tannock IF. ASCO core values. J Clin Oncol 2006 Dec 20; 24(36):5780-2
PMID: 17179111
Li FP, Fletcher JA, Heinrich MC, Garber JE, Sallan SE, Curiel-Lewandrowski C, Duensing A, van de Rijn M, Schnipper LE, Demetri GD. Familial gastrointestinal stromal tumor syndrome: phenotypic and molecular features in a kindred. J Clin Oncol 2005 Apr 20; 23(12):2735-43
PMID: 15837988
Gilligan TD, Carrington MA, Sellers TP, Casal L, Schnipper LE, Li FP. Cancer survivorship issues for minority and underserved populations. Cancer Epidemiol Biomarkers Prev 2003 Mar; 12(3):284s-286s
PMID: 12646528
Eder JP, Supko JG, Clark JW, Puchalski TA, Garcia-Carbonero R, Ryan DP, Shulman LN, Proper J, Kirvan M, Rattner B, Connors S, Keogan MT, Janicek MJ, Fogler WE, Schnipper L, Kinchla N, Sidor C, Phillips E, Folkman J, Kufe DW. Phase I clinical trial of recombinant human endostatin administered as a short intravenous infusion repeated daily. J Clin Oncol 2002 Sep 15; 20(18):3772-84
PMID: 12228197
Merchan JR, Chan B, Kale S, Schnipper LE, Sukhatme VP. In vitro and in vivo induction of antiangiogenic activity by plasminogen activators and captopril. J Natl Cancer Inst 2003 Mar 5; 95(5):388-99
PMID: 12618504
External Recognition:
St. George Medal, American Cancer Society, for major contributions to Cancer Care
Public Service Award, American Society of Clinical Oncology
Statesman Award, American Society of Clinical Oncology
Chair, ASCO Ethics Committee
Chair, ASCO Task Force on Cost of Cancer Care
Theodore and Evelyn Berenson Professor of Medicine, Harvard Medical School
Associate Director, Membership, Dana Farber Harvard Cancer Center
Deputy Associate Director for Clinical Sciences, Daa Farber Harvard Cancer Center
Member, Executive Committee, Dana Farber Harvard Cancer Center
Major Collaborative Activities:
Associate Director for Membership, DFHCC
Deputy Associate Director for Clinical Sciences, DFHCC
