We use basic immunology tools to: 1.) study the fundamental basis of T cell tolerance; 2.) design agents and regimens that create T cell tolerance and; 3.) use expression profiling molecular diagnostic strategies to help achieve tolerance through analysis of the host and allograft at the time of implantation and serially thereafter.
Bettelli E, Carrier Y, Gao W, Korn T, Strom TB, Oukka M, Weiner HL, Kuchroo VK. reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 2006 May 11; 441(7090) 235-8.
Korn T, Bettelli E, Gao W, Awasthi A, Jäger A, Strom TB, Oukka M, Kuchroo VK. IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells. Nature. 2007; 448: 484-487.
Gao W, Lu Y, El Essawy B, Oukka M, Kuchroo VK, Strom TB. Contrasting effects of cyclosporine and rapamycin in de novo generation of alloantigen-specific regulatory T cells. Am J Transplant. 2007; 7:1722-32.
Zhong M, Gao W, Degauque N, Bai C, Lu Y, Kenny J, Oukka M, Strom TB, Rothstein TL. Reciprocal generation of Th1/Th17 and Treg cells by B1 and B2 B cells. Eur J Immunol 2007; 37: (in press).
Koulmanda, M., E. Budo, S. Bonner-Weir, A. Qipo, R. Putheti, N. Degauque, H. Shi, Z. Fan, J.S. Flier, H. Auchincloss, X.X. Zheng, and T.B. Strom. Modification of adverse inflammation is required to cure new-onset type 1 diabetic hosts. Proc Natl Acad Sci USA; 2007 (e-pub Aug 1).
External Recognition:
1- United States Senate appointed Task Force on Transplantation .
2- Chair, United States Senate appointed Task Force on Transplantation subcommittee on immunosuppressive medications.
3- Roche Distinguished Achievement Award from the American Society of Transplantation
4- Homer Smith Award from the American Society of Nephrology fror lifetime achievement in science.
5- Lilly Prize from the Royal College of Physicians (London)
6- Sandoz Transplant Established Investigator Award from the American Society of Transplantation
7- Past President, American Society of Transplantation
8- Past President, Clinical Immunology Society
9- Councillor, International Society of Nephrology10-Councillor, Transplantation Society
10- Steering Committee, NIH/ JDRF funded Immune Tolerance Network
11- Chair, Tolerance Assay Committee,NIH/ JDRF funded Immune Tolerance Network
Major Collaborative Activities:
JDRF funded collaboration with Hugh Auchincloss (MGH) in primate transplantation models.
NIH funded collaboration with Mo Sayegh (BWH) in murine transplant models.
NIH funded collaboration with Joren Madsen(MGH,) Mo Sayegh (BWH), David Sachs (MGH) and Ben Cosimi (MGH) in primate transplant models.
NIH funded collaboration with Bill Harmon(CH) and Mo Sayegh (BWH-CH) inclinically useful biomnarker discovery in human transplant recipients.
Collaboration with Charles Lin (MGH) in imaging the allograft response.
JDRF funded collaboration with Diane Mathis (JDC) and Vijay Kuchroo (BWH)
NIH funded collaboration with Towia Libermann (BWH)
Collaboration with Simon Robson (BIDMC) on the molecular signature and mode of action of regulatory T cells
