Daniel G. Tenen is Professor of Medicine at Harvard Medical School, as well as Director of the Blood Program of the Harvard Stem Cell Institute, Director of the Cancer Biology Program at Beth Israel Deaconess Medical School, co-Director of the Harvard Medical School Hematology Training Grant, and Distinguished Visiting Professor at the National University of Singapore. His research efforts have focused on transcription factors, gene regulation, and their role in normal differentiation and cancer. His research contributions have included establishing the role of transcription factors in differentiation of myeloid cells and the role of disruption of these pathways in leukemia and lung cancer. Major keywords: gene regulation, hematopoiesis, leukemia, cancer
Bassères DS, Levantini E, Ji H, Monti S, Elf S, Dayaram T, Fenyus M, Kocher O, Golub T, Wong KK, Halmos B, Tenen DG. Respiratory failure due to differentiation arrest and expansion of alveolar cells following lung-specific loss of the transcription factor C/EBPa in mice. 2006: Molecular and Cellular Biology 26:1109-1123.
Radomska HS, Bassères DS, Zheng R, Zhang P, Dayaram T, Yamamoto Y, Sternberg DW, Lokker N, Giese NA, Bohlander S, Schnittger S, Delmotte MH, Davis RJ, Small D, Hiddemann W, Gilliland DG, Tenen DG. Block of C/EBPa Function by Phosphorylation in Acute Myeloid Leukemia with FLT3. 2006: J Exp Med 203:371-381
Steidl U, Rosenbauer F, Verhaak RGW, Gu X, Ebralidze A, Otu HH, Klippel S, Steidl C, Bruns I, Costa DB, Wagner K, Aivado M, Kobbe G, Valk PJ, Passegué E, Libermann TA, Delwel R, Tenen DG. Essential role of Jun family transcription factors in PU.1-induced leukemic stem cells. 2006. Nature Genet 38:1269-1277.
Steidl U, Steidl C, Ebralidze A, Chapuy B, Han HJ, Will B, Rosenbauer F, Becker A, Wagner K, Koschmieder S, Kobayashi S, Costa DB, Schulz T, O’Brien KB, Verhaak RGW, Delwel R, Haase D, Truemper L, Krauter J, Kohwi-Shigematsu T, Griesinger F, Tenen DG. A distal single nucleotide polymorphism alters long-range regulation of the PU.1 gene in acute myeloid leukemia. 2007: J Clin Invest 117:2611-2620.
Huang G, Zhang P, Hirai H, Elf S, Yan X, Chen Z, Koschmieder S, Okuno Y, Dayaram T, Growney JD, Shivdasani RA, Gilliland DG, Speck NA, Nimer SD, Tenen DG. PU.1 is a major downstream target of AML1 (RUNX1) in adult mouse hematopoiesis. 2008: Nature Genet 40:51-60.
External Recognition:
Scholar, Leukemia Society of America
NIH study section and Leukemia Society reviewer
Major Collaborative Activities:
Leukemia Program Project (DFCI)
LLS SPORE (DFCI)
Lung SPORE (DFCI)
