My main research interest is the vascular reactivity of the micro- and macrocirculation. I direct the development of the Microcirculation Lab, which test the microvasculature in a non-invasive way. The Lab is also equipped with ultrasound apparatus that enables us to evaluate the endothelial function of the brachial artery. In addition to the above, I am also the research Director of teh Joslin-Beth israel Deaconess Foot center and i am interested in the etiology of diabetic foot problems and the pathophysiology of wound healing in diabetes. I am also interested in the development of diabetic neuropathy and its interaction with skin microcirculation.
Caballero AE, Arora S, Saouaf R, Lim SC, Smakowski P, Park JY, King GL, LoGerfo FW, Horton ES, Veves A. Micro- and macro-vascular reactivity is impaired in subjects at risk for type 2 diabetes. Diabetes 1999:48:1863-1867
Veves A, Akbari CM, Primavera J, Donaghue VM, Zacharoulis D, Chrzan JS, DeGirolami U, LoGerfo FW, Freeman R. Endothelial dysfunction and the expression of endothelial nitric oxide synthetase in diabetic neuropathy, vascular disease and foot ulceration. Diabetes 1998; 47:457-463
Szab� C, Zanchi A, Komj�ti K, Pacher P, Krolewski AS, Quist WC, LoGerfo FW, Horton ES, Veves A. Poly (ADP-Ribose) polymerase is activated in subjects at risk of developing type 2 diabetes and is associated with impaired vascular reactivity. Circulation 2002;106:2680-2686.
Greenman RL, Panasyuk S, Wang X, Lyons TE, Dinh T, Longoria L, Giurini JM, Freeman J, Khaodhiar L, Veves A. Early changes in the skin microcirculation and muscle metabolism of the diabetic foot. Lancet, 2005;366:1711-17
Economides PA, Khaodhiar L, Caselli A, Caballero AE, Keenan H, Bursell S, King GL, Johnstone MT, Horton ES, Veves A. The effect of vitamin E on the endothelial function of the micro- and macro-circulation and the left ventricular function of type 1 and 2 diabetic patients. Diabetes 2005; 54:204-211
External Recognition:
Major Committee Assignments
1999- Research Grant Review Committee of the Juvenile Diabetes Research Foundation International, member
2002- Grant Review Panel, American Diabetes Association, member
2004- Ad hoc member, NHLBI Mentored Patient Oriented Research Career Development Award Panel for K23, K24 and K25 applications and R13 Conference Grants
2005 Member, NHLBI Special Emphasis Panel. Specialized Centers of Clinically-Oriented Research in Vascular Injury, Repair, and Remodeling.
2005 Member, Wentworth Institute of Technology Electromechanical Engineering Industrial Professional Advisory Committee
2005 Special Emphasis Panel 2006/01 ZDK1 GRB-1 (J3), Podiatry Summer Research Fellowships
2006 NIGMS Special Emphasis Panel. Centers for Innovative Wound Healing Research. Member
2006 Scientific Merit Review, Veterans Affairs, Rehabilitation Research and Development (RR&D) Service
Awards and Honors
2002 Mary Jane Kugel Award by the Juvenile Diabetes Research Foundation International for participation in Medical Science Review Committee.
2002 Chennai Diabetes Research Centre Gold Medal Oration Award
2004 Roger Pecoraro Lecture for my contribution to research on the field of diabetic foot problems.
a. Invited presentations
2003 Neuropathy and Microvascular Disease. At Symposium on Advanced Wound Care. Las Vegas. (contact time 30 minutes, 1500 participants).
Endothelial Dysfunction and the Microcirculation. At the Consensus Development Conference on PVD in Diabetes, organized by the American Diabetes Association. (contact time 40 minutes, 150 participants).
Diabetes and Cardiovascular Disease. At Renal Division Seminar Conferences,, Medical Center of University of Vermont. (contact time 60 minutes, 25 participants).
Skin Microcirculation and Wound Healing. At Wound Healing Workshop, organized by DARPA, NIH (NIDDK, NIGM) and Juvenile Diabetes Research Foundation. Annapolis MD, September 2003. (contact time 20 minutes, 50 participants).
The role of Microcirculation in Diabetic Foot Pathology. At Diabetic Foot Management. Harvard Medical School. Boston, MA, November 2003 (contact time 20 minutes, 250 participants).
New Concepts in Skin Microcirculation Abnormalities in Diabetes. Wound Healing: Science and Industry. St. Thomas, VI. December 2003 (contact time 30 minutes, 80 participants).
2004 Endothelial dysfunction in diabetes. 5th Boston Vascular Fellows Basic Science Seminar. Boston, January 2004 (contact time 60 minutes, 15 participants).
Endothelial function in the microcirculation in diabetes. Elli Lilly and Company. Indianapolis, Indiana, March 2004 (contact time 60 minutes, 20 participants).
Vascular And Metabolic Changes In The Diabetic Foot. (RFA HL-03-003) Clinical Research in Peripheral Arterial Disease Grantees' Meeting, Bethesda, MD, March 2004. (contact time 30 minutes, 30 participants).
Roger Pecoraro Lecture. American Diabetes Association 64th Annual Scientific Sessions. Orlando, FL, June 2004, (contact time 45 minutes, 300 participants).
Microvascular Dysfunction in the Diabetic Foot. Is It Clinically Significant? At: New Cardiovascular Horizons and management of the diabetic foot and wound healing. Louisiana Podiatric Medical Association, New Orleans, LA, October 2004. (contact time 30 minutes, 500 participants).
The role of Microcirculation in Diabetic Foot Pathology. At Diabetic Foot Management. Harvard Medical School. Boston, MA, November 2004 (contact time 30 minutes, 200 participants).
Vascular Abnormalities in the Diabetic Foot. At: The Diabetic Foot. Update 2004: A Multidisciplinary Approach. Dept of Orthopedics, The University of Texas Health Science Center at San Antonio, Texas, December 2004. (contact time 30 minutes, 250 participants).
Skin Microcirculation Abnormalities in Diabetes. Wound Healing: Science and Industry. St. Thomas, VI. December 2004. (contact time 30 minutes, 75 participants).
2005 Vascular Abnormalities and Wound Healing. Diabetic Vascular Disease and Wound Complications. European Tissue Repair Society and Vascular Medicine Research Group, University of Southampton, UK, March 2005. (contact time 30 minutes, 75 participants).
Diabetes and Vascular Disease. IX Congress Of Vascular Problems, Risk Factor And Diabetic Foot. Buenos Aires, Argentine, May 2005 (contact time 30 minutes, 350 participants).
Pathogenesis and Treatment of the Diabetic Foot Ulcer. IX Congress Of Vascular Problems, Risk Factor And Diabetic Foot. Buenos Aires, Argentine, May 2005 (contact time 60 minutes, 400 participants).
Animal Models in Wound Healing (Organizer, Chair and Introduction). American Diabetes Association 65th Annual Scientific Sessions. San Diego, CA, June 2005, (contact time 15 minutes, 200 participants).
Vascular And Metabolic Changes In The Diabetic Foot � Progress Report. (RFA HL-03-003) Clinical Research in Peripheral Arterial Disease Grantees' Meeting, Chicago, IL, June 2005. (contact time 30 minutes, 150 participants).
Brigham and Women�s Plastic Surgery Research Team Meeting. �Microcirculation in the Diabetic Foot�. Boston, MA, September 2005 (contact time 60 minutes, 20 participants).
Microcirculation Abnormalities in Charcot Neuroarthropathy. At: The Diabetic Foot. Update 2005: A Multidisciplinary Approach. Dept of Orthopedics, The University of Texas Health Science Center at San Antonio, Texas, December 2005. (contact time 30 minutes, 250 participants).
Tissue Oxygenation and Foot Muscle Metabolism Abnormalities in Diabetes. Wound Healing: Science and Industry. St. Thomas, VI. December 2005. (contact time 30 minutes, 100 participants).
2006 Effect of oxidative stress, statins and other therapeutic interventions on the endothelial function in diabetes. At: Semmelweis Symposium: Nitric Oxide and Nitrosative Stress in the Cardiovascular System. Budapest, Hungary, October (contact time 30 minutes, 200 participants)
Animal Models of Wound Healing in Diabetes. Wound Healing: Science and Industry. St. Thomas, VI. December 2006. (contact time 30 minutes, 100 participants).
b. Professional and educational leadership
1998 Member of the Organizing Committee of Advances in Wound Care Meeting. Atlanta, GA. This is a multidisciplinary conference devoted exclusively to the management of wounds. The main goal is to help practitioners involved in wound care learn how to translate the concept of quality into clinical decision making that can have a positive effect on practice-and a measurable impact on outcomes of patient care.
1999 Planning Committee member of the Consensus Development Conference on Diabetic Foot Wound Care, organized by the American Diabetes Association. The main goal of this meeting was to develop a consensus that will help in the management of diabetic foot ulcers.
2001- Meeting Committee member of Wound Healing: Science and Industry. St. Thomas, VI. This is an interdisciplinary meeting that allows opinion leaders to discuss and interact with various professionals in academics and industry.
2001. American Diabetes Association Expert Committee on Foot Wound Classification, member
2002. Planning Committee member of the Consensus Development Conference on PVD in Diabetes, organized by the American Diabetes Association. The main goal of this meeting was to develop a consensus that will help in the management of peripheral vascular disease in the diabetic foot.
2006 Member of the Wound Healing Society Panel that developed the Guidelines for the Treatment of Diabetic Ulcers
Major Collaborative Activities:
I collaborate Frank W. LoGerfo and his team at Vascular Surgery, BIDMC, Robert Greenman and Neil Rofsky, Department of Radiology, BIDMC, Roy Freeman and Seward Rutkove, Neurology, BIDMC and Atul Malhotra and his team, Brigham and Womens Hospital.
