This laboratory, directed by Dr. Peter Weller, has many active areas of basic laboratory research centered around understanding basic mechanisms of leukocyte functioning in forms of inflammation. The two principal areas of investigation are: 1) the immunobiology of eosinophilic leukocytes and 2) the intracellular regulation and compartmentalization of inducible mediators of inflammation in neutrophils and other leukocytes. Studies of human eosinophils are aimed at defining mechanisms whereby eosinophils may collaboratively interact with other cellular elements of the immune system.
Shi HZ, Humbles A, Gerard C, Jin Z, Weller PF. Lymph node trafficking and antigen presentation by endobronchial eosinophils. J Clin Invest 2000; 105:945-953.
Bandeira-Melo C, Sugiyama K, Phoofolo M, Weller PF. Extranuclear lipid bodies, elicited by CCR3-mediated signaling pathways, are the sites of chemokine-enhanced leukotriene C4 production in eosinophils and basophils. J Biol Chem 2001; 276:22779-22787.
Bandeira-Melo C, Woods LJ, Phoofolo M, Weller PF. Intracrine cysteinyl leukotriene receptor-mediated signaling of eosinophil vesicular transport-mediated interleukin-4 secretion. J Exp Med 2002; 196:841-850..
Bandeira-Melo C, Woods LJ, Weller PF. Cutting Edge: Eotaxin elicits rapid, vesicular transport-mediated release of preformed IL-4 from human eosinophils. J Immunol. 2001; 166:4813-4817.
