Human monoclonal antibody against HIV gp120 (clones F223, F424, F425A1, F425B4A1g8, F425B4e8) (BIDMC 1303)

Category:    Research Reagents

KeyWords:  Antibody;  Infectious Deseases; AIDS;  Screeing Method;  

BIDMC ID:    1303

Abstract:

All clones produced in human cell line. F223: Antibody reacts with HIV envelope proteins but it is not clear whether it is gp-120 or gp41. The antibody does not neutralize HIV. F424: Antibody reacts with HIV envelope proteins but it is not clear whether it is gp-120 or gp41 but does not neutralize HIV. F425A1: This antibody produced in human cell line neutralizes HIV upon binding to the v3 loop of gp120. F425B4A1g8: Produced in human cell line. This HIV neutralizing antibody reacts to the g120 epitope exposed upon CD4 binding. F425B4e8: This antibody binds to V3 loop of gp120 and it potentially neutralizes HIV.

Inventor:   Lisa Cavacini, Marshall Posner

Commercial Opportunity:

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State of Development:

Related Technology URL:

http://research.bidmc.harvard.edu/research/ResearchPIInfo.ASP?Submit=Display&PersonID=102

Patent Status:

not filed

TVO Contact Info:
     Jodi E Hecht
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     jehecht@bidmc.harvard.edu
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     Beth Israel Deaconess Medical Center
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