Transgenic mice expressing the cre gene in POMC neurons (BIDMC 1315)

Category:    Research Tools

KeyWords:  Animal Model;  Obesity;  Metabolic Diseases;  

BIDMC ID:    1315

Abstract:

The POMC-cre mouse is an ideal research tool to study the effect of tissue specific targeted gene deletion in proopiomelanocortin (POMC) neurons by using the Cre/lox system.

Inventor:   Brad Lowell, MD, PhD

Commercial Opportunity:

Competitive Advantages:

Related Publications:

Balthasar N, Coppari R, McMinn J, Liu SM, Lee CE, Tang V, Kenny CD, McGovern RA, Chua SC Jr, Elmquist JK, Lowell BB.  Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis.  Neuron, 42:  983-91, 2004.

State of Development:

Related Technology URL:

http://research.bidmc.harvard.edu/research/ResearchPIInfo.ASP?Submit=Display&PersonID=439

Patent Status:

not filed

TVO Contact Info:
     Jodi E Hecht
     Licensing Associate
     jehecht@bidmc.harvard.edu
     Phone: 617-667-4197   Fax: 617-667-0646

     Beth Israel Deaconess Medical Center
     Technology Ventures Office  Room: BR-0200
     330 Brookline Avenue
     Boston, MA 02215