Melanocortin 4 receptor knockout mice (loxTB-MC4R mice) (BIDMC 1316)

Category:    Research Tools

KeyWords:  Animal Model;  Obesity;  Metabolic Diseases;  

BIDMC ID:    1316

Abstract:

The endogenous gene melanocortin 4 receptor is transcriptionally blocked by loxp sites. Expression of melanocortin 4 receptor can be restored by breeding this strain with cre-recombinase expressed in the hypothalamus.

Inventor:   Brad Lowell, MD, PhD

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Related Technology URL:

http://research.bidmc.harvard.edu/research/ResearchPIInfo.ASP?Submit=Display&PersonID=439

Patent Status:

not filed

TVO Contact Info:
     Jodi E Hecht
     Licensing Associate
     jehecht@bidmc.harvard.edu
     Phone: 617-667-4197   Fax: 617-667-0646

     Beth Israel Deaconess Medical Center
     Technology Ventures Office  Room: BR-0200
     330 Brookline Avenue
     Boston, MA 02215