Human monoclonal antibody against desmoglein 3 (clone PVMAB786) (BIDMC 1341)

Category:    Research Reagents

KeyWords:  Antibody;  Allergy;  

BIDMC ID:    1341

Abstract:

Pemphigus vulgaris (PV) is a potentially fatal autoimmune mucocutaneous disease associated with production of IgG autoantibodies to desmoglein 3 (Dsg3). PVMAB786 will be a valuable tool in identifying the role of Dsg3 in epithelial cell adherence and acantholysis, mechanisms of Dsg3 processing/presentation and V gene and isotype usage in PV pathogenesis. The antibody reacts with a 130-kDa protein on keratinocyte cell surfaces and recombinant Dsg3 protein, but not desmoglein 1 protein.

Inventor:   Lisa Cavacini, Ph.D.

Commercial Opportunity:

Competitive Advantages:

Related Publications:

Yeh, Shih-Wei et al 2006 Pathogenic human monoclonal antibody against desmoglein 3. Clinical Immunology  vol. 120, no1, pp. 68-75

State of Development:

available for non-exclusive licensing

Related Technology URL:

Patent Status:

no patent filed

TVO Contact Info:
     Jodi E Hecht
     Licensing Associate
     jehecht@bidmc.harvard.edu
     Phone: 617-667-4197   Fax: 617-667-0646

     Beth Israel Deaconess Medical Center
     Technology Ventures Office  Room: BR-0200
     330 Brookline Avenue
     Boston, MA 02215