Title: Clinical Trial of Approaches to Prostate Cancer Surgery

Brief Title: Clinical Trial of Approaches to Prostate Cancer Surgery

Brief Summary: This is a prospective, randomized controlled trial to compare cancer control and health-related quality of life following pelvic fascia-sparing radical prostatectomy versus standard radical prostatectomy. The investigators hypothesize that pelvic fascia-sparing radical prostatectomy will have similar cancer control (primary outcome) and sexual function outcomes; and significantly better urinary function, penile shortening/deformity and inguinal hernia risks as compared to radical prostatectomy.

Title: A Phase 3, Randomized Study of Adjuvant Cretostimogene Grenadenorepvec versus Observation for the Treatment of Intermediate Risk Non-Muscle Invasive Bladder Cancer (IR-NMIBC) Following Transurethral Resection of Bladder Tumor (TURBT)

Brief Title: A Study of Adjuvant Cretostimogene Grenadenorepvec for Treatment of Intermediate Risk NMIBC Following TURBT

Brief Summary: This is a Phase 3, open-label, randomized trial designed to evaluate the RFS of TURBT followed by cretostimogene grenadenorepvec versus TURBT followed by surveillance for the treatment of participants with IR-NMIBC.

Title: An Objective and Subjective Assessment of the Financial Burden of Thyroid Cancer

Brief Title: Financial Burden of Thyroid Cancer

Title: Randomized controlled trial assessing transperineal prostate biopsy to reduce infection complications

Brief Title: PReclude Infection EVEnts With No Prophylaxis Transperineal Biopsy 2

Brief Summary: Approximately one million transrectal prostate biopsies are performed annually in the U.S., and the risk of post- biopsy infection is increasing due to greater antibiotic resistance of rectal flora. Preliminary data demonstrates that a transperineal MRI-targeted biopsy approach under local anesthesia compared to the standard practice transrectal MRI-targeted prostate biopsy has a much lower risk of infection, comparable pain/discomfort and may improve detection of prostate cancer. This randomized controlled trial will be the first prospective study to evaluate in-office transperineal MRI targeted prostate biopsy. The investigators hypothesize that a transperineal MRI-targeted biopsy approach under local anesthesia compared to the standard practice transrectal MRI-targeted prostate biopsy has a much lower risk of infection, comparable pain/discomfort and may improve detection of prostate cancer.

Title: A Phase 1/2a Study of STM-416 Administered Intraoperatively to Patients Undergoing Transurethral Resection of Bladder Tumor (TURBT) for Recurrent High-Grade Papillary Bladder Cancer.

Brief Title: A Study of STM-416 Administered to Patients Undergoing TURBT for Recurrent Bladder Cancer

Brief Summary: This is a first-in-human (FIH), Phase 1/2a, multi center, open-label, single treatment, dose escalation and expansion study designed to determine the safety and tolerability of STM-416 in patients with bladder cancer.

Title: Blue Light Cystoscopy With Cysview® (BLC with Cysview®) Registry

Brief Title: Blue Light Cystoscopy With Cysview® Registry

Brief Summary: Registry study to gather more information on the current use of Blue Light Cystoscopy with Cysview (BLCC) in urologists' practices.

Title: Feasibility and Efficacy of the AveCure Flexible Microwave Ablation Probe for Peripheral Lung Nodules

Brief Title: Avecure Flexible Microwave Ablation Probe For Lung Nodules

Brief Summary: This research study to determine the effectiveness of the AveCure Flexible Microwave Ablation Probe to destroy cancerous lung nodules up to 3 c m in size. This research study involves microwave ablation (MWA)

Title: Local Bisphosphonate Effect on Recurrence Rate in Extremity Giant Cell Tumor of Bone: A Prospective Randomized Controlled Trial

Brief Title: Local Bisphosphonate Effect on Recurrence Rate in Extremity Giant Cell Tumor of Bone

Brief Summary: The purpose of the clinical study is to investigate whether the local delivery of bisphosphonate as a surgical adjuvant can decrease the chance of a giant cell tumor of bone coming back to the same location. The hypothesis is that the local administration of bisphosphonate will decrease the rate of the tumor returning compared to traditional aggressive surgical removal of the tumor.

Title: Variable anatomy & function of the arm's alternate lymphatic pathway

Brief Title: Mapping and Quantifying Lymphatic Drainage of the Arm's Alternate Pathway

Brief Summary: Using indocyanine green (ICG) lymphography and lymphoscintigraphy with SPECT/CT imaging, the aim is to evaluate the anatomy of the lymphatic system pathway in two separate populations: healthy female volunteers and women with a history of breast cancer who did not develop lymphedema.

Title: Edrn Prostate MRI Biomarker Study And Reference Set

Brief Title: EDRN Prostate MRI Biomarker Study

Brief Summary: The commercialization of MRI fusion biopsies has resulted in a dramatic increase in the use of MRI imaging for prostate cancer. How best to use MRI in the initial prostate biopsy setting given the availability of validated prostate cancer early detection markers is uncertain.This study will allow investigators to determine if prostate MRI is superior to validated panel of laboratory biomarkers (e.g. PCA3, PSA and TMPRSS2:ERG) in the initial biopsy setting.

Title: Validating axillary imaging in determining disease burden of advanced axillary disease in Breast cancer

Brief Title: Validating axillary imaging in determining disease burden of advanced axillary disease in Breast can

Title: Impact of a Multidisciplinary Clinic in Management of Patients with New Diagnoses of Pancreatic Cancer

Brief Title: MULTIDISCIPLINARY CLINIC IN MANAGEMENT OF PTS W NEW DIAGNOSES OF PANCREATIC CANCER

Title: Effectiveness of Open and Robotic Prostatectomy: The PROSTQA-RP2 Cohort Study

Brief Title: Effectiveness of Open and Robotic Prostatectomy

Brief Summary: Prostate cancer is the most common cancer in American men. Surgical removal of the entire prostate (prostatectomy) is one option among the various ways to treat prostate cancer. The use of robot assistance for prostatectomy has become common place, but its effectiveness has not been compared to standard open prostatectomy in trials carried out at more than one medical institution in which participants are identified and followed forward in time. Robot assisted and standard open prostatectomy health related quality of life (HRQOL) outcomes have not been compared in a prospective, multi-centered study. Prostatectomy can have side effects that can change with time. This research study seeks to determine how common and how long-lasting such side effects are; to find out what features of individual men's cancers and what features of the treatments affect those side effects. This study also seeks to identify factors that affect the quality of prostate cancer care by looking at how satisfied men are with their prostate cancer care. Through these findings, this study aims to allow treatment side effects to be anticipated more accurately for individual patients, and to provide a means for determining the quality of prostate care.

Title: Canary Prostate Active Surveillance Study

Brief Title: Canary Prostate Active Surveillance Study