Title: A Pilot Study To Assess The Effect Of Antepartum Perineal Massage Using A Pelvic Wand On Labor Agency And Pelvic Health

Brief Title: Perineal Massage Intervention

Brief Summary:

Title: Infant Vaccine Biorepository

Brief Title: Infant Vaccine Biorepository

Brief Summary: The Infant Vaccine Biorepository is an observational study and the purpose is to better understand how long infant immune protection transferred through the placenta (from mother to baby) after maternal infection or vaccination lasts. We will research infections like influenza (the flu), pertussis (Whooping Cough), and SARS-CoV-2 (COVID-19), and others. You will be asked to collect a blood sample from your baby at home at 3-5 months-old, 6-8 months-old, and 9-12 months-old, using an investigational device for blood collection. The device will collect blood from the smallest blood vessels (the capillaries). The consenting parent will also have the option to test the device. Participation in this study will last until your baby is 1 year old. Compensation for participation is included.

Title: Mpox Tissue and Data Repository

Brief Title: Mpox Tissue and Data Repository

Brief Summary: The purpose of this study is to collect samples and clinical information for storage in a repository from individuals with a suspected or confirmed diagnosis of Monkeypox, individuals who recovered from Monkeypox, and individuals who received or plan to receive a vaccine against Monkeypox.

Title: Miracle of life study: Observational study of pregnant women to validate biomarkers of pregnancy complication risk

Brief Title: MIRACLE of LIFE Study

Brief Summary: The primary objective of this study is to clinically verify and validate Mirvies cfRNA-based classifiers that predict the risk of a woman developing complications including preeclampsia, preterm birth, and gestational diabetes during her pregnancy. The putative classifiers were identified in a whole transcriptome discovery study of over 3,000 women completed in 2020. Subjects must be pregnant with a singleton pregnancy between 18-22 weeks gestation at time of enrollment to be eligible for this study.

Title: Measures of maternal immune function in fresh and stored blood samples

Brief Title: Immune response in fresh and stored blood

Brief Summary: This prospective cohort study seeks to determine whether immune function throughout pregnancy can be measured at the time of blood collection and also on blood that has been stored. The samples are analyzed using Treg assays on fresh peripheral blood samples and cytokine assays on stored plasma. Results will be compared to determine how measures of immune function from stored samples correlated to results from fresh samples. Participants must be pregnant with plans to deliver at BIDMC.

Title: COVID-19 and Other Respiratory Pathogens Biorepository

Brief Title: COVID-19 and Other Respiratory Pathogens Biorepository

Brief Summary: The purpose of this study is to establish a biorepository of specimens and clinical data from potential, confirmed, or convalescent Coronavirus disease 2019 (COVID-19) cases and from those vaccinated with a COVID-19 vaccine. The study recruits and enrolls special populations including individuals who are pregnant or lactating and who are receiving vaccines against COVID-19 infection.

Title: Randomized controlled trial of panniculus retraction methods for cesarean delivery

Brief Title: Panniculus retraction of cesarean delivery

Brief Summary: This prospective, open-label, randomized-controlled trial is designed to evaluate the use of the Traxi panniculus retractor-- a commercially available Class I FDA-exempt device will improve surgical outcomes, cardiopulmonary function, and provider/patient satisfaction in morbidly obese women undergoing cesarean delivery.