Title: Evaluation of Long-term Neuropsychologic and Cognitive Outcomes in Patients with Unruptured Intracranial Aneurysms

Brief Title: Neuropsychologic Outcomes for UIAs

Brief Summary: The aim of this study is to investigate neurocognitive effects of UIA treatment in patients receiving elective treatment at BIDMCs Neurosurgical Department for UIAs. Therefore, a longitudinal study design has been chosen, in which 200 patients across two sites will be evaluated neuropsychologically on 3 separate occasions: on first clinic visit, 3 months after diagnosis or treatment, and 1 year after diagnosis or treatment. This information will be gathered and evaluated for outcomes of neurocognitive functioning after treatment.

Title: Pivotal Study to Evaluate the Safety and Effectiveness of the CereVasc eShunt System in the Treatment of Normal Pressure Hydrocephalus (STRIDE)

Brief Title: STRIDE E-Shunt Study

Brief Summary: Prospective, multi-center, randomized, controlled trial of the eShunt System in the treatment of patients with normal pressure hydrocephalus.

Title: Treatment Resistant Depression Subcallosal Cingulate Network DBS

Brief Title: TRANSCEND Study

Brief Summary: The goal of this clinical trial is to evaluate the effectiveness and safety of bilateral stimulation of the subcallosal cingulate white matter (SCCwm) using Deep Brain Stimulation (DBS) as an adjunctive treatment of non-psychotic unipolar Major Depressive Disorder (MDD) in adults.

Title: A First-in-human (FIH) Study of Inhibitory Interneurons (NRTX-1001) in Drug-Resistant Unilateral Mesial Temporal Lobe Epilepsy (MTLE)

Brief Title: NTE001

Brief Summary: This clinical trial is designed to test whether a single image-guided intracerebral administration of inhibitory nerve cells, called interneurons (NRTX-1001), into subjects with drug-resistant unilateral mesial temporal lobe epilepsy (MTLE), with or without mesial temporal sclerosis (MTS), is safe (frequency of adverse events) and effective (seizure frequency). NRTX-1001 comprises human interneurons that secrete a neurotransmitter, gamma-aminobutyric acid (GABA).