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Title: Community and Household Acute Respiratory Illness Monitoring (CHARM) Study
Brief Title: CHARM Study
Brief Summary: The CHARM Study is an observational study to gather important data on respiratory viral illnesses in communities in the Greater Boston Area. We will study how often respiratory viral illnesses occur - like COVID19 and influenza - and how these viruses are spread. Our goal is to improve public health interventions to prevent disease.
For info regarding 2025P000360
please contact Center for Virology and Vaccine Research at 617-735-4610 or
cvvrtrials@bidmc.harvard.edu
Title: A Data and Tissue Repository to Facilitate Infectious Diseases Research and Advance Pandemic Preparedness, with a Focus on Respiratory Pathogens
Brief Title: A Data and Tissue Repository for Respiratory Pathogens
Brief Summary: The purpose of this study is to collect samples and clinical information from people with symptoms of an acute respiratory illness, such as cough, fever and muscle pain. These are symptoms that are typical of influenza, COVID-19 and other viral infections. We are also collecting samples from people without any symptoms. The goal of the study is to store these samples to help researchers prepare for future outbreaks of infectious diseases.
For info regarding 2023P001078
please contact Center for Virology and Vaccine Research at 617-735-4610 or
cvvrtrials@bidmc.harvard.edu
Title: General Pre-Trial Screening Protocol for Enrollment of Volunteers into Infectious Diseases Research Protocols
Brief Title: General Pre-Trial Screening Protocol
Brief Summary: The purpose of this general screening protocol is to facilitate recruitment into studies conducted at the Center for Virology and Vaccine Research (CVVR) at BIDMC. This protocol will help us to determine whether a volunteer is eligible for completing the screening process, and which protocols they may be good candidates for.
For info regarding 2023P000266
please contact Center for Virology and Vaccine Research at 617-735-4610 or
cvvrtrials@bidmc.harvard.edu
Title: HVTN 307: A phase 1 clinical trial to evaluate the safety and immunogenicity of ferritin nanoparticles expressing native-like HIV-1 envelope trimers followed by boost with mRNA lipid nanoparticles encoding a native-like HIV-1 envelope trimer in adults without HIV
Brief Title: HVTN 307
Brief Summary: This first-in-human (FIH) phase 1 clinical trial will evaluate a prime-boost regimen of
immunogens designed to induce HIV-1 Env V3-glycan-specific broadly neutralizing
antibodies (V3G bNAbs). The priming immunogen (V3G CH848 Pr-NP1) consists of ferritin NPs
expressing 8 copies of an Env trimer. This immunogen will be boosted with an mRNA LNP
(V3G CH848 mRNA-Tr2), encoding a soluble Env trimer which does not utilize the ferritin
NP design.
For info regarding 2023C000500
please contact Center for Virology and Vaccine Research at 617-735-4610 or
cvvrtrials@bidmc.harvard.edu