Title: A Phase 2a Randomized, Dose Ranging, Double-Blind, 3-Arm Study to Investigate Orally Administered Abrocitinib Compared with Placebo in Non-Hospitalized Symptomatic Adult Participants with Severe Fatigue from Post COVID Condition

Brief Title: CLEAR-LC CLinical Eval Abrocitinib Recovery from Long COVID

Brief Summary: The primary purpose of this phase 2a study is to compare the efficacy of abrocitinib to placebo in improving severe fatigue in non-hospitalized adults with symptomatic Post-COVID Condition (PCC) (also called Long COVID). We are also interested in learning if abrocitinib is effective in improving overall health status in people suffering from severe fatigue from PCC. Eligible participants with a confirmed history of COVID19 infection who also have PCC according to the World Health Organization definition, will be randomized to receive abrocitinib at a dose of 50 mg, 100 mg, or placebo by mouth daily for 12 weeks (84 days).

Title: A Data and Tissue Repository to Facilitate Infectious Diseases Research and Advance Pandemic Preparedness, with a Focus on Respiratory Pathogens

Brief Title: A Data and Tissue Repository for Respiratory Pathogens

Brief Summary: The purpose of this study is to collect samples and clinical information from people with symptoms of an acute respiratory illness, such as cough, fever and muscle pain. These are symptoms that are typical of influenza, COVID-19 and other viral infections. We are also collecting samples from people without any symptoms. The goal of the study is to store these samples to help researchers prepare for future outbreaks of infectious diseases.

Title: Characterizing non-restorative sleep in post-viral disease to advance intervention innovations

Brief Title: Nonrestorative sleep in post-viral disease

Brief Summary: This study is being done to understand why people with (ME/CFS) and Long COVID may experience nonrestorative sleep. Non-restorative sleep means that you do not feel refreshed or well rested after sleeping. We hope to learn more about things that might affect your sleep. For example, how your bodys systems, such as your immune system (the system that helps you fight infections) and hormones (chemicals that signal different functions in your body) are related to non-restorative sleep. We hope that learning more about non-restorative sleep can help with future treatment.

Title: Infant Vaccine Biorepository

Brief Title: Infant Vaccine Biorepository

Brief Summary: The Infant Vaccine Biorepository is an observational study and the purpose is to better understand how long infant immune protection transferred through the placenta (from mother to baby) after maternal infection or vaccination lasts. We will research infections like influenza (the flu), pertussis (Whooping Cough), and SARS-CoV-2 (COVID-19), and others. You will be asked to collect a blood sample from your baby at home at 3-5 months-old, 6-8 months-old, and 9-12 months-old, using an investigational device for blood collection. The device will collect blood from the smallest blood vessels (the capillaries). The consenting parent will also have the option to test the device. Participation in this study will last until your baby is 1 year old. Compensation for participation is included.

Title: SARS-CoV-2 Household Transmission Study

Brief Title: SARS-CoV-2 Household Transmission Study

Brief Summary: We are conducting this study to see how SARS-CoV-2 is transmitted from one person to another within a household, and to see if COVID-19 vaccination can help prevent SARS-CoV-2 transmission. We are enrolling people who have recently tested positive for COVID-19 (or were recently exposed or have symptoms of COVID-19), as well as people who live in a household with someone who potentially might have COVID-19. The study lasts up to 4 weeks. If you participate, we will ask you to swab your nose every day for 14 days so we can test for COVID19. We will also ask for a couple blood draws, but these are optional. You would receive up to $50 to compensate you for participation.

Title: Long-Term Endothelial Effects of COVID-19 in Obesity

Brief Title: Long-Term Endothelial Effects of COVID-19 in Obesity

Brief Summary: The CLEO study examines the long-term effects of COVID-19 infection and whether these effects are different in people who have obesity compared to people who do not have obesity. Participation in the study will involve a physical exam, IV placement with blood sampling, cell collection from a vein, ultrasound, and cardiac PET adn will take approximate 1 to 4 study visits over 1 to 6 months at BIDMC and Brigham and Womens Hospital BWH).

Title: Yogic Breathing and Guided Meditation for Long Covid Symptoms

Brief Title: Covid No Longer

Brief Summary: This study aims to assess the impact of brief digitally delivered breathing practice and guided meditation on post-Covid physical and mental symptoms in Long Covid Patients.

Title: COVID-19 and Other Respiratory Pathogens Biorepository

Brief Title: COVID-19 and Other Respiratory Pathogens Biorepository

Brief Summary: The purpose of this study is to establish a biorepository of specimens and clinical data from potential, confirmed, or convalescent Coronavirus disease 2019 (COVID-19) cases and from those vaccinated with a COVID-19 vaccine. The study recruits and enrolls special populations including individuals who are pregnant or lactating and who are receiving vaccines against COVID-19 infection.