Title: Characterizing body temperature across the menstrual cycle in reproductive-age day and night shift working nurses
Brief Title: Temperature in day and night shift working women
Brief Summary: We invite female nurses in the Longwood Medical Area between the ages of 18-35 to consider participating in this study. Specifically, we are seeking nurses who work only day or only night shifts, who are not taking hormonal birth control, and who are not pregnant or actively trying to become pregnant. The study will be conducted in the BIDMC Clinical Research Center and will involve brief, in-person study visits, body temperature collection across the menstrual cycle using different types of temperature collection devices, questionnaires, and urine sample collection.
This study is being done to understand whether female nurses between the ages of 18 and 35, who work night-shifts, show temperature irregularities across their menstrual cycle, compared to those nurses who work more standard, day shifts. The study will also help us determine whether peripheral temperature recording devices accurately reflect the internal core body temperature (and potential temperature irregularities that may occur when working night shifts). Learning more about temperature dynamics across the menstrual cycle of both day and night-shift working females could help with future fertility treatments, given that many night-shift working women experience infertility.
For info regarding 2025P000624
please contact Sydney Aten, PhD at
saten@bidmc.harvard.edu
Title: Transforming Adolescent Perception and Mental Health through Meditation and Cognitive Reappraisal A Mixed Method Study
Brief Title: THRIVE
Brief Summary: This study will evaluate how a comprehensive meditation-based program, Inner Engineering,
supports teens ages 15-18 in becoming more joyful, focused, resilient, and better
equipped to manage stress and thrive. Through this study, researchers will examine
whether practices like meditation, yoga, and cognitive reframing can help adolescents
view and respond to challenges with greater clarity and balance. The study will assess
mental and physical impacts through self-report, physiological, and neuroimaging methods.
For info regarding 2025P000560
please contact Hemavarne Shankhar at
hshankha@bidmc.harvard.edu
Title: Community and Household Acute Respiratory Illness Monitoring (CHARM) Study
Brief Title: CHARM Study
Brief Summary: The CHARM Study is an observational study to gather important data on respiratory viral illnesses in communities in the Greater Boston Area. We will study how often respiratory viral illnesses occur - like COVID19 and influenza - and how these viruses are spread. Our goal is to improve public health interventions to prevent disease.
For info regarding 2025P000360
please contact Center for Virology and Vaccine Research at 617-735-4610 or
cvvrtrials@bidmc.harvard.edu
Title: Brain Age Sleep Indices of Longitudinal Cognition
Brief Title: BASILsC
Brief Summary: The main goal of this study is to explore how sleep affects memory, attention, and overall brain function in adults by using two wearable and non-invasive devices called Muse S, and Oura Ring. The Muse S is a headband that tracks your brain activity; and the Oura Ring is a ring that tracks your breathing, heart rate, sleep quality, recovery, and overall wellness. Well collect data on your sleep and heart health for up to 20 nights within 3
months and will also ask you to complete mental tasks the morning after. By doing this, we hope to find patterns that could help us understand what healthy brain aging looks like and to spot early signs of memory or thinking problems. This research could lead to ways to support brain health and prevent issues as we get older.
For info regarding 2025P000336
please contact Kaileigh Gallagher at
kgallag2@bidmc.harvard.edu
Title: A Phase 2, Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety and Efficacy of ABBV-CLS-628 in Adult Subjects with Autosomal Dominant Polycystic Kidney Disease (ADPKD)
Brief Title: Study of ABBV-CLS-628 in Adults with ADPKD
Brief Summary: Autosomal Dominant Polycystic Kidney Disease (ADPKD) is the most common genetic cause of
kidney disease that causes fluid-filled cysts to develop in the kidneys. The purpose of
this study is to assess the safety and efficacy of ABBV-CLS-628 for the treatment of
ADPKD in adult participants.
ABBV-CLS-628 is an investigational drug being developed for the treatment of ADPKD.
Participants are placed in 1 of 4 groups, called treatment arms. Each group receives a
different treatment. There is a 1 in 4 chance that participants will be assigned to
placebo. Around 240 adult participants with ADPKD will be enrolled at approximately 100
sites worldwide.
Participants will receive IntraVenous ABBV-CLS-628 or placebo every 4 weeks for 92 weeks.
Participants will be followed for up to 15 weeks.
There may be higher treatment burden for participants in this trial compared to their
standard of care . Participants will attend regular visits during the study at a hospital
or clinic. The effect of the treatment will be checked by medical assessments, blood
tests, checking for side effects and completing questionnaires.
For info regarding 2025P000270
please contact Peter Czarnecki at 617-667-8378 or
pczarnec@bidmc.harvard.edu
Title: Imaging Biomarkers of Glymphatic Function in Patients with Migraine
Brief Title: Glymphatic MRI
Brief Summary: The main goal is to determine whether glymphatic imaging biomarkers are altered in migraine patients (compared to healthy controls), and whether those markers differ in chronic vs. episodic migraine patients. The study activities include a screening visit, at which you will answer some questions about your migraines (if you have a diagnosis of migraines), and an MRI scan.
For info regarding 2025P000195
please contact Narjes Jaafar at
njaafar@bidmc.harvard.edu
Title: Investigating Electrophysiological Markers for Depressive Rumination as Noninvasive Brain Stimulation (NIBS) Treatment Targets
Brief Title: FLEX Rumination
Brief Summary: By participating, you will help us investigate brain activity patterns associated with cognitive flexibility, a process which allows humans to switch tasks or perspectives. An additional, optional part of this study also seeks to evaluate the potential of non-invasive brain stimulation as a tool to alter brain activity patterns, with the goal of reducing depressive rumination and suicidal ideation. We are looking for individuals with recent (6 months) diagnosis of major depressive disorder or persistent depressive disorder, and healthy volunteers
For info regarding 2024P000910
please contact Ling-Yu Huang, PhD at 617-754-1259 or
lhuang11@bidmc.harvard.edu
Title: Development of a clinical experimental heat stress protocol and exploration of the effect of Niacinamide on physiologic, metabolic, and biochemical responses to heat stress
Brief Title: Experimental heat stress metabolomics and the effect of Nam
Brief Summary: The goal of this clinical trial is to learn about the processes occurring in the kidneys
while under heat stress in healthy volunteers. The main questions it aims to answer are:
- How do the chemicals produced by the body change under conditions of higher versus
lower heat stress?
- What role does a specific area of the body's metabolism, known as NAD+ metabolism,
play in the body's response to heat stress, and can this response be modified by
taking vitamin B3?
For info regarding 2024P000637
please contact Nathan Raines at 617-632-9880 or
nraines@bidmc.harvard.edu
Title: Investigating Changes in Anxiety, Sleep Duration and Quality after Shoonya Meditation Practice
Brief Title: RESET
Brief Summary: This study aims to investigate the effects of Shoonya Meditation (taught by the Isha Foundation) on sleep, anxiety, and stress through validated surveys, and sleep data. The control group will consist of individuals who have learned and practice Shambhavi Mahamudra Kriya, also offered by the Isha Foundation.
For info regarding 2024P000521
please contact Alex-Maree Roberts at
amrobert@bidmc.harvard.edu
Title: Development of physical therapy telehealth program for patients at risk of falls NIA-JHAITC
Brief Title: NIA-JHAITC
For info regarding 2024P000470
please contact Dennis Anderson, PhD at 617-975-7623 or
danders7@bidmc.harvard.edu
Title: Wearable Evaluation of Ambulatory Readings for Blood Pressure
Brief Title: WEAR - BP
Brief Summary: The aim of this project is to serve as a quality control measure, assessing the accuracy and reliability of novel cuffless Blood Pressure monitoring devices. These devices will be evaluated in comparison to the established standard, Spacelabs Ambulatory Blood Pressure Monitoring (ABPM) device. This assessment is crucial to ensure the trustworthiness and suitability of the new devices for upcoming research projects. Up to 250 participants (at least 100) will be involved in this study each wearing up to 7 devices (6 BP and 1 activity monitor). The assignment of devices will be randomized by day and by the arm or wrist on which they are worn.
For info regarding 2024P000441
please contact Frederick Labri Kwapong at
flarbitw@bidmc.harvard.edu
Title: Immune and metabolic characterization of patients with alcohol-associated hepatitis
Brief Title: Characterization of AH
Brief Summary: This research study aims to establish a clinical database and biorepository to gain a deeper understanding of the causes and mechanisms of illnesses like alcoholic-associated hepatitis and other diseases. This involves the collection of blood samples (referred to as biological samples) and personal health information from both healthy and sick participants for potential use in future investigations into alcoholic-associated hepatitis or other diseases. A biological sample typically refers to blood but may include any bodily fluid. Personal Health Information encompasses details such as name, age, gender, race, and medical history, as well as data from prior research participation or routine medical examinations.
For info regarding 2024P000164
please contact Ruchi Chauhan at 617-735-2886 or
rchauhan@bidmc.harvard.edu
Title: Enhancing Sleep in Older Adults Using Auditory and Transcranial Stimulation: A Machine Learning Approach
Brief Title: Enhancing sleep in older adults with noninvasive stimulation
Brief Summary: The main purpose of this study is to explore the effects of noninvasive brain stimulation (neuromodulation) on slow wave sleep and cognition. The types of brain stimulation that will be used are auditory stimulation (AS) and transcranial alternating current stimulation (tACS). The AS device, SleepLoop, and tACS device, Starstim, involved in this study are investigational. This study will investigate whether AS and tACS can affect slow waves (a type of brain activity that occurs during deep sleep and is closely linked to memory and learning) during sleep to improve short-term cognition.
For info regarding 2024P000148
please contact Stephanie Buss, MD at
sbuss@bidmc.harvard.edu
Title: A Data and Tissue Repository to Facilitate Infectious Diseases Research and Advance Pandemic Preparedness, with a Focus on Respiratory Pathogens
Brief Title: A Data and Tissue Repository for Respiratory Pathogens
Brief Summary: The purpose of this study is to collect samples and clinical information from people with symptoms of an acute respiratory illness, such as cough, fever and muscle pain. These are symptoms that are typical of influenza, COVID-19 and other viral infections. We are also collecting samples from people without any symptoms. The goal of the study is to store these samples to help researchers prepare for future outbreaks of infectious diseases.
For info regarding 2023P001078
please contact Center for Virology and Vaccine Research at 617-735-4610 or
cvvrtrials@bidmc.harvard.edu
Title: Evaluation of Vaccine induced Immune Activity against SARS-CoV-2 and RSV (IVY-6-sera)
Brief Title: IVY-6 Vaccine Activity
Brief Summary: The purpose of this study is to understand immune responses in people who receive FDA-approved SARS-CoV-2 (COVID) or RSV vaccines. This will help figure out if the SARS-CoV-2 or RSV vaccines will work against the viruses. We also want to figure out if your immune response is protective against new forms of the virus. We will obtain blood from individuals vaccinated against SARS-CoV-2 or RSV who meet eligibility criteria before
vaccine dose, at 3 to 6 weeks after a vaccine dose and/or 12 to 16 weeks after a vaccine dose. For SARS-CoV-2, the collection of blood from fully vaccinated individuals will help ensure that the data generated from antigenic studies is consistent and can be compared over time.
For info regarding 2023P001072
please contact ED Research Team at 6170650-0042 or
cottanel@bidmc.harvard.edu
Title: Cognitive Function and Affective Regulation in Meditators
Brief Title: CALM
Brief Summary: This research is being done to assess the impact of meditation practice on cognitive function and emotional regulation. We are also looking to assess its impact on positive and negative emotions, feelings of stress, anxiety, and depression. You will be asked to complete a set of online cognitive tasks as well as a detailed survey at a singular time-point after the time of consent.
For info regarding 2023P000588
please contact Ashwin Swaminathan at 617-278-8150 or
Sadhgurucenter_research@bidmc.harvard.edu
Title: Eyecontrol coMmunication platform for dEliRium manaGemEnt in intensive care units (EMERGE) : A Multicenter Randomized Controlled Trial
Brief Title: EMERGE
Brief Summary: The purpose of this research is to investigate whether addition of the EyeControl-Pro
platform as an adjunct to standard guideline-based intensive care unit management of
critically ill patients is effective in reducing delirium incidence and severity.
For info regarding 2023P000563
please contact Somnath Bose at 617-667-7600 or
sbose2@bidmc.harvard.edu
Title: Cardiometabolic disease and heart failure with preserved ejection fraction
Brief Title: BI HFpEF
Brief Summary: This is a prospective observational study of 250 patients receiving care at BIDMC who have heart failure with preserved ejection fraction (HFpEF). The aim of the study is to better understand the link between cardiometabolic disease and HFpEF. At each visit, we will conduct a physical exam and perform a blood draw, and participants will complete a health questionnaire to assess quality of life. There will be up to 3 study visits over the course of 3 months. About 1 year after enrollment, participants will be re-contacted for a telephone health survey.
For info regarding 2023P000392
please contact Ndidi Owunna at 617-735-4126 or
nowunna@bidmc.harvard.edu
Title: A First-in-human (FIH) Study of Inhibitory Interneurons (NRTX-1001) in Drug-Resistant Unilateral Mesial Temporal Lobe Epilepsy (MTLE)
Brief Title: NTE001
Brief Summary: This clinical trial is designed to test whether a single image-guided intracerebral
administration of inhibitory nerve cells, called interneurons (NRTX-1001), into subjects
with drug-resistant unilateral mesial temporal lobe epilepsy (MTLE), with or without
mesial temporal sclerosis (MTS), is safe (frequency of adverse events) and effective
(seizure frequency). NRTX-1001 comprises human interneurons that secrete a
neurotransmitter, gamma-aminobutyric acid (GABA).
For info regarding 2023P000349
please contact Joshua Aronson at 617-632-7023 or
jaronson@bidmc.harvard.edu
Title: Tablet application for the screening and monitoring of movement disorders
Brief Title: Drawing Analysis for Screening of Parkinsons Disease
Brief Summary: We are trying to develop a way to measure movement disorders in people (e.g. Parkinsons Disease). We are testing people on a variety of drawing tasks using an iPad and a stylus. We plan to analyze how people perform on the tasks. We will use this information to create more accurate, faster, and more convenient tasks and determine whether these drawing tasks will provide us with information that is useful in understanding which movement disorder a patient has or whether they do not have a movement disorder.
For info regarding 2023P000280
please contact Jay Iyer at
jiyer@bidmc.harvard.edu
Title: General Pre-Trial Screening Protocol for Enrollment of Volunteers into Infectious Diseases Research Protocols
Brief Title: General Pre-Trial Screening Protocol
Brief Summary: The purpose of this general screening protocol is to facilitate recruitment into studies conducted at the Center for Virology and Vaccine Research (CVVR) at BIDMC. This protocol will help us to determine whether a volunteer is eligible for completing the screening process, and which protocols they may be good candidates for.
For info regarding 2023P000266
please contact Center for Virology and Vaccine Research at 617-735-4610 or
cvvrtrials@bidmc.harvard.edu
Title: A Phase 1a/1b Single Ascending and Multiple Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of Topical OA-3, a PAR2 Inhibitor, in Adult Healthy Volunteers and Subjects with Atopic Dermatitis and Pruritus
Brief Title: Phase 1a/1b Study Efficacy of Topical OA-3, a PAR2 Inhibitor
Brief Summary: The purpose of this study is to help us understand the safety and the potential effectiveness a new topical study drug called OA-3 hydrogel for the treatment of atopic dermatitis (AD), or eczema. This study will be open to atopic dermatitis patients and healthy patients.
For info regarding 2023P000228
please contact Martina Porter at 617-667-5834 or
clears@bidmc.harvard.edu
Title: Narrow band green light effects on cortical excitability and responsivity in migraine
Brief Title: Narrow band greenlight
For info regarding 2023P000201
please contact Rami Burstein, PhD at
rburstei@bidmc.harvard.edu
Title: Department of Neurology Biorepository
Brief Title: Department of Neurology Biorepository
Brief Summary: The purpose of this study is to collect and store samples (for example, blood and saliva) in patients with different neurologic disorders (for example, Parkinsons Disease, Epilepsy, Stroke) to be used for future research to learn more about diagnosing, preventing and treating neurologic disorders.
For info regarding 2023P000108
please contact Neurology Biorepository Research Team at 617-667-0605 or
NeuroRepository@bidmc.harvard.edu
Title: Characterizing non-restorative sleep in post-viral disease to advance intervention innovations
Brief Title: Nonrestorative sleep in post-viral disease
Brief Summary: This study is being done to understand why people with (ME/CFS) and Long COVID may experience nonrestorative sleep. Non-restorative sleep means that you do not feel refreshed or well rested after sleeping. We hope to learn more about things that might affect your sleep. For example, how your bodys systems, such as your immune system (the system that helps you fight infections) and hormones (chemicals that signal different functions in your body) are related to non-restorative sleep. We hope that learning more about non-restorative sleep can help with future treatment.
For info regarding 2022P001036
please contact Janet Mullington, PhD at 617-667-5243 or
postviralsleep@bidmc.harvard.edu
Title: Infant Vaccine Biorepository
Brief Title: Infant Vaccine Biorepository
Brief Summary: The Infant Vaccine Biorepository is an observational study and the purpose is to better understand how long infant immune protection transferred through the placenta (from mother to baby) after maternal infection or vaccination lasts. We will research infections like influenza (the flu), pertussis (Whooping Cough), and SARS-CoV-2 (COVID-19), and others. You will be asked to collect a blood sample from your baby at home at 3-5 months-old, 6-8 months-old, and 9-12 months-old, using an investigational device for blood collection. The device will collect blood from the smallest blood vessels (the capillaries). The consenting parent will also have the option to test the device. Participation in this study will last until your baby is 1 year old. Compensation for participation is included.
For info regarding 2022P000765
please contact Dr. Ai-ris Collier at
CVVRtrials@bidmc.harvard.edu
Title: BRANCH: Brain Age and Sleep Architecture in Meditators
Brief Title: BRANCH: Brain Age and Sleep Architecture in Meditators
Brief Summary: This is a single-center, cross-sectional study that will recruit approximately fifty
seven (57) meditators and fifty one (51) controls. Individuals that have learned at least
the Shambhavi Mahamudra Kriya practice and live in Massachusetts will be mailed a DREEM
EEG device, and a sleepimage ring. Participants will be asked to wear the two devices
while sleeping for three consecutive weekday nights (Sunday night to Thursday night) and
two weekend nights (Friday and Saturday nights). While meditating during the day,
participants will only wear the DREEM EEG headband. Participants will also undergo
neurocognitive tests from the NIH toolbox during one virtual visit via video call.
Meditators who join the study will be asked to invite a control subject to the study,
matched for age and comorbidities.
For info regarding 2022P000597
please contact Sepideh Hariri, PhD at 617-667-2721 or
sadhugurucenter_research@bidmc.harvard.edu
Title: Mpox Tissue and Data Repository
Brief Title: Mpox Tissue and Data Repository
Brief Summary: The purpose of this study is to collect samples and clinical information for storage in a repository from individuals with a suspected or confirmed diagnosis of Monkeypox, individuals who recovered from Monkeypox, and individuals who received or plan to receive a vaccine against
Monkeypox.
For info regarding 2022P000577
please contact Center for Virology & Vaccine Research at 617-735-4610 or
CVVRtrials@bidmc.harvard.edu
Title: Brain Health with Inner Engineering- Longitudinal Study of Shambhavi Mahamudra Kriya Meditation (BLISS)
Brief Title: BLISS
Brief Summary: This study will explore whether a 21-minute meditation practice called Shambhavi
Mahamudra Kriya leads to changes in brain health and explore how it affects cognitive and
physiological function.
For info regarding 2022P000296
please contact Sepideh Hariri at 617-278-8082 or
shariri1@bidmc.harvard.edu
Title: Audio Markers of Speech and Cognition in Neurodegenerative Disease (Audio-ND)
Brief Title: Audio-HD
Brief Summary: The purpose of this research is to establish biomarkers (a medical sign that can be measured reliably) for both speech and cognitive impairment in Huntingtons disease using a speech analyzing application. Participants must either have a confirmed genetic diagnosis of Huntingtons disease or be
a heathy volunteer. Participants will undergo demographics and medical history review, cognitive tests, questionnaires, and a 10-minute speech assessment.
For info regarding 2022P000181
please contact Luis Sierra at 617-667-2351 or
hdresearch@bidmc.harvard.edu
Title: The Impact of Insufficient Sleep and Insomnia Disorder on Behavioral and Neural Markers of Emotion Regulation
Brief Title: The Effect of Sleep Loss on Emotion
Brief Summary: The study is designed to investigate the impact of three nights of sleep restricted to 4
hours per night, on the processing and regulation of emotional information compared to
Insomnia Disorder and control. The investigators will address and attempt to answer two
questions.
(i) How do three nights of reduced sleep or a diagnosis of Insomnia Disorder affect the
processing and regulation of emotional information compared to typical, undisturbed
sleep? (ii) What overlapping and distinct neural mechanisms are engaged and associated
with behavioral effects when attempting to process and regulate emotions in a sleep
restricted state or with a clinical diagnosis of Insomnia Disorder? This study will
investigate sleep's role in emotion processing and regulation. The findings will help
further understanding of the role of sleep in healthy emotional functioning.
For info regarding 2022P000120
please contact Anthony Cunningham, PhD at (617)667-4702 or
acunnin4@bidmc.harvard.edu
Title: SARS-CoV-2 Household Transmission Study
Brief Title: SARS-CoV-2 Household Transmission Study
Brief Summary: We are conducting this study to see how SARS-CoV-2 is transmitted from one person to another within a household, and to see if COVID-19 vaccination can help prevent SARS-CoV-2 transmission. We are enrolling people who have recently tested positive for COVID-19 (or were recently exposed or have symptoms of COVID-19), as well as people who live in a household with someone who potentially might have COVID-19. The study lasts up to 4 weeks. If you participate, we will ask you to swab your nose every day for 14 days so we can test for COVID19. We will also ask for a couple blood draws, but these are optional. You would receive up to $50 to compensate you for participation.
For info regarding 2022P000021
please contact Center for Virology and Vaccine Research at 617-735-4610 or
cvvrtrials@bidmc.harvard.edu
Title: REST: Resilience to Sleep Deprivation and Changes in Sleep Architecture in Shoonya Meditators
Brief Title: Sleep Architecture in Shoonya Meditators
Brief Summary: This study aims to investigate the effect of a 15-minute meditation practice on sleep
architecture and high-frequency Heart Rate Variability (HF-HRV), as well as cognitive
performance after both a well-rested and sleep-deprived night.
For info regarding 2021P000544
please contact Akshaj Joshi at 617-278-8058 or
sadhgurucenter_research@bidmc.harvard.edu
Title: Variable anatomy & function of the arm’s alternate lymphatic pathway
Brief Title: The M-S Pathway: anatomy and function
For info regarding 2021P000209
please contact Angela Chen at 617-632-7827 or
lymphaticresearch@bidmc.harvard.edu
Title: COVID-19 and Other Respiratory Pathogens Biorepository
Brief Title: COVID-19 and Other Respiratory Pathogens Biorepository
Brief Summary: The purpose of this study is to establish a biorepository of specimens and clinical data from potential, confirmed, or convalescent Coronavirus disease 2019 (COVID-19) cases and from those vaccinated with a COVID-19 vaccine. The study recruits and enrolls special populations including individuals who are pregnant or lactating and who are receiving vaccines against COVID-19 infection.
For info regarding 2020P000361
please contact Ai-Ris Collier, MD at (617) 735-4610 or
CVVRtrials@bidmc.harvard.edu
Title: Retinal Layer, Microvascular and Electroretinographic Determinants of Early Course Psychosis
Brief Title: Retinal Determinants of Early Course Psychosis
Brief Summary: Schizophrenia is a chronic disorder and is among the most highly disabling diseases in all of medicine, impacting approximately 1.5% of the population. This study will use novel state-of-the-art Electroretinography (ERG), Optical Coherence Tomography (OCT) and angiography (OCTA) imaging to capture retinal biomarkers that inform pathophysiology and clinical outcome in early course psychosis. This study is expected to have an impact on the growing consensus in psychiatry and neuro-ophthalmology that the retina provides a window into the brain that can be useful for understanding brain pathophysiology and for developing biomarkers of illness progression and possibly treatment response.
For info regarding 2019P000815
please contact Brendan Stiltner at 617-754-1232 or
bstiltne@bidmc.harvard.edu
Title: The Effect of Sleep Deprivation and Recovery Sleep on Emotional Memory and Affective Reactivity
Brief Title: The Effect of Sleep Deprivation on Emotional Processing
Brief Summary: To further understand the impact of acute sleep deprivation and recovery sleep on the
processing of emotional information the investigators will address and attempt to answer
three questions, (i) how both undisturbed sleep and sleep deprivation affect the
processing and retrieval of emotional information, (ii) what neural and
psychophysiological mechanisms are associated with these behavioral effects, and (iii) to
explore the ability of recovery sleep to reverse the effects of sleep deprivation.
Together, these studies will provide a greater breadth and depth of knowledge concerning
sleep's role in emotion processing and regulation. Given the growing societal tendency to
view sleep as unproductive-foregoing it to lengthen work days and increase social
opportunities- such knowledge would be of practical importance for understanding the role
of sleep in healthy emotional functioning, particular for individuals experiencing
periods of increased stress and emotional distress (e.g., new parents, hospital staff, or
combat troops).
For info regarding 2019P000062
please contact Robert Stickgold at 617-632-7926 or
rstickgo@bidmc.harvard.edu
Title: MRI Evaluation of Aging Related Changes to the Brain
Brief Title: MRI Evaluation of Aging Related Changes to the Brain
Brief Summary: The purpose of this study is to develop new magnetic resonance imaging (MRI) techniques that can be used to clinically evaluate patients across a spectrum of ages 18+. This study will test magnetic resonance techniques on FDA approved MRI machines. Newly developed MRI sequences will be
validated on normal subject brains and compared to standard techniques. This study will evaluate different brain imaging techniques including Arterial Spin Labeling (ASL) perfusion and Inhomogeneous Magnetization Transfer (ihMT) imaging.
For info regarding 2017P000491
please contact David Alsop at 617-667-0275 or
dalsop@bidmc.harvard.edu
Title: The evolution of memories across wake and sleep
Brief Title: The evolution of memories across wake and sleep
Brief Summary: To further understanding of the relationship between sleep and memory the investigators
will address and attempt to answer three questions, (1) how memories evolve across wake
and sleep, (2) how different aspects of this memory evolution are reflected both
behaviorally and in the EEG signal, and (3) what stages and features of sleep affect
memory evolution. Together, these studies will provide a greater breadth and depth of
knowledge concerning sleep's role in memory consolidation. Such knowledge would be of
practical importance for educational practices, whether in schools, on the job, or in the
military, and would also provide valuable information to the fields of sleep medicine and
psychiatry, where interactions between sleep disorders and cognitive functioning are of
great importance.
For info regarding 2016P000222
please contact Anthony Cunningham, PhD at 617-667-4702 or
acunnin4@bidmc.harvard.edu
Title: Studies of Immune Cell Signaling and Gene Transcription in Systemic Lupus Erythematosus, Other Autoimmune Diseases and Healthy Volunteers
Brief Title: Blood Samples in Lupus, other Autoimmune Diseases
Brief Summary: This study is being done to study the natural history of Systemic Lupus Erythematosus (SLE). The causes of and the treatments for the disease will be investigated and compared to those of other autoimmune diseases and healthy controls without any autoimmune disease. Participants will be asked to donate blood (less than or equal to 100 mLs) and/or urine while they are having their clinical labs drawn, no less than every 6 weeks.
For info regarding 2006P000298
please contact Rheumatology Clinical Research Specialist at 617-632-8658 or
skrishfi@bidmc.harvard.edu