Wenyi Wei, PhD
Principal Investigator
Pathology
Contact Information
| Office: | CL-637 |
| Phone: | 617-735-2495 |
| Fax: | 617-735-2480 |
| Email: | wwei2@bidmc.harvard.edu |
| Address: | 330 Brookline Ave; CL-637
Boston, MA 02215 |
Areas of Interest
| 1 Cancer |
Major Research Theme
| The major focus of research in my new laboratory will be aimed at understanding how APC and SCF activities contribute towards cell cycle regulation and subsequent tumor formation. More specifically, I am interested in elucidating the underlying mechanisms that define the oscillation of APC and SCF activity in different cell cycle phases. Currently I am pursuing the underlying mechanisms that timely regulate APC/Cdh1 activity in different cell cycle phases. Additionally, I am also interested in understanding whether other layers of crosstalk between the APC and SCF complex exist. Furthermore, I would like to identify novel downstream targets for both APC and SCF complexes, which will help pinpoint their functions in both cell cycle control and tumor formation. To this end, I have developed biochemical purification approaches that would allow me to identify novel downstream targets for APC/Cdh1 and SCF/Fbw7 complexes. In addition, I am also interested in defining the tumor suppressor function of Cdh1 utilizing conditional Cdh1 knockout mice. To achieve these goals, my lab will use multidisciplinary approaches including biochemical and genetic analysis. In the long term, I hope that a better understanding of the multilayer regulation of the delicate proteolysis pathways will lead us to the design of more efficient intervention strategies to combat cancer and other diseases. |
Publications
External Recognition
| 2005-2007 Claudia Adams Barr Award (This award is terminated after I left Dana-Farber at Oct. 2006) 2005-2008 Leukemia and Lymphoma Society Special Fellow Jan.-Dec. 2007 Milton Fund Award, Harvard Medical School 2007-2009 Kimmel Scholar 2007-2009 Emerald Foundation New Investigator Award 2008-2011 MLSC New Investigator Award |
Investigator's Lab Web Site
| Research Lab URL | None listed |
| Harvard Catalyst Site: | Wei Harvard Catalyst Web Site |
