Robert C Flaumenhaft, MD,PhD
Associate Professor
Hemostasis & Thrombosis
Contact Information
| Office: | CL-0939 |
| Phone: | 617-667-0627 |
| Fax: | 617-735-4005 |
| Email: | rflaumen@bidmc.harvard.edu |
| Address: | 330 Brookline Ave; CL-0939
Boston, MA 02215 |
Advanced Degree And Training
| Year | Institution | Area or Rank |
| 1993 | New York University | PhD/MD |
| 1993 | New England Medical Center | Resident |
| 1995 | New England Medical Center | Fellow |
| 1997 | BIDMC/Harvard Medical School | Post-doctoral fellow |
| 1999 | BIDMC/Harvard Medical School | Instructor |
| 2000 | BIDMC/Harvard Medical School | Assistant Professor |
Research Lab Team Members
| Bruce Furie MD | Glenn Merrill-Skoloff MA |
Areas of Interest
| 1 Cancer |
Major Research Theme
| My laboratory is focused on several themes pertaining to platelet biology. First, we are interested in understanding the molecular basis of platelet granule secretion. To explore this problem, we have developed a permeabilized platelet model that we have used to identify molecules necessary for platelet granule secretion. Second, we have used a chemical genetic approach in order to identify signal cascades that are critical for thrombus formation in live animals. We have screened for and identified small molecules that inhibit platelet function and are presently assessing the effect of these compounds in an intravital mouse model of laser-induced thrombosis. These studies have lead us to evaluate the role of protein palmitoylation in platelet activation. Third, we are investigating the physiology of platelet microparticles. Specifically, we are determining whether platelet microparticles are derived directly from megakaryocytes and evaluating the mechanism of clearance of platelet microparticles. Finally, we are interested in using labeled platelets to visualize atherothrombotic disease in clinically relevant models. |
Publications
External Recognition
| Honors 1996 Postdoctoral Research Fellowship for Physicians, Howard Hughes Medical Institute 1999 Clinical Investigator Track Program 1999 Burroughs Wellcome Fund Career Award 2002 American Society of Hematology Junior Faculty Scholar Award 2005 The Bayer Hemophilia Awards Program, Special Project Award 2006 Grant-In-Aid, American Heart Association, Northeast Affiliate 2008 Established Investigator Award, American Heart Association, National Committee Assignments 1999 Anticoagulation Subcommittee, BIDMC 2001 Editorial Board, Hematology/Oncology, Primary Care Update for Ob/Gyn 2004 Center for Scientific Review Special Emphasis Panel 2005 Hemostasis and Thrombosis Study Section, Ad hoc Member 2005 Clinical Hematology Review, Special Emphasis Panel – Heme-B, Ad hoc Member 2006 Signaling Pathways in Platelets, Special Emphasis Panel, Ad hoc Member 2006 Reviewer, Session in Platelet Activation, American Society of and Biochemistry Hematology 2007 Scientific Program Committee, International Society of Thrombosis and Haemostasis Selected Presentations 2000 Gordon Conference on Hemostasis, Invited Symposium Lecturer 2002 Gordon Conference on Hemostasis, Invited Symposium Lecturer 2001 Department of Biology Lecture Series, Boston College 2003 Cardiovascular Research Lecture Series, St. Elizabeth’s Medical Center 2004 Blood Research Center Lecture Series, The Blood Center of Southeastern Wisconsin 2005 Mechanisms of Thrombosis, Invited Symposium Lecturer |
Major Collaborative Activities
| We collaborate with: Joseph Italiano, Ph.D., Brigham and Women's Hospital, to study megakaryocyte production of microparticles. Bruce M.D. and Barbara Furie Ph.D., BIDMC, to study thrombus formation using intravital microscopy. Broad Institute, to study small molecule inhibitors of platelet activation and thrombosis. |
Investigator's Lab Web Site
| Research Lab URL | None listed |
| Harvard Catalyst Site: | Flaumenhaft Harvard Catalyst Web Site |
