Aria F Olumi, MD
Division Chief
Urologic Surgery
Contact Information
| Office: | RA-0413 |
| Phone: | 617-667-4075 |
| Fax: | 617-975-5570 |
| Email: | aolumi@bidmc.harvard.edu |
| Address: | 330 Brookline Ave; RA-0413
Boston, MA 02215 |
Advanced Degree And Training
| Year | Institution | Area or Rank |
| 1992 | University of Southern California | Medicine |
| 1992 | Harvard Program in Urology | Urology/Surgery Resident |
| 1995 | UCSF Med Center | Molecular Med Research |
| 2000 | Harvard Program in Urology | Chief Resident -- Urology |
Research Lab Team Members
| Ignacio San Francisco MD |
Areas of Interest
| 1 Cancer |
Major Research Theme
|
1. TNF-related Apoptosis Inducing Ligand (TRAIL) has been shown to induce apoptosis in a variety of tumorigenic and transformed cell lines but not in normal cells, hence making TRAIL an ideal cancer therapeutic agent with minimal cytotoxicity. FLICE Inhibitory Protein (c-FLIP) is an important regulator of TRAIL-induced apoptosis. We have demonstrated that persistent expression of c-FLIP(L) is inversely correlated with the ability of TRAIL to induce apoptosis in prostate cancer cells. In a series of correlative and functional studies we have shown that persistent expression of c-FLIP(L) is necessary and sufficient to regulate sensitivity to TRAIL mediated apoptosis in prostate cancer cells. Deciphering the molecular mechanisms of resistance to TRAIL can improve the efficacy of pro-apoptotic agents in treatment of malignancies. 2. A second project in the lab focuses on stromal-epithelial interactions in prostate cancer tumor progression. We have shown that fibroblasts associated with prostatic carcinoma can promote progression from preneoplasia to neoplasia. We are focusing on identifying the signal transduction pathways important in stromal-epithelial interactions in melignant and benign prostatic disease. |
Publications
External Recognition
| 1989 & 90 Baxter Foundation Research Award 1990 National Medical Student Research Award, Phi Delta Epsilon Medical Soc. 1991 Medical Student Research Award 1997 Young Investigator's Award, Society of Basic Urologic Research 1998 Young Investigator's Award, American Assc. Of Cancer Research 1999 Countway Library Urology Resident Research Award, First Place 2000 Countway Library Urology Resident Research Award, First Place 2000- Reviewer--Journal of Urology 2002 Grant Reviewer Dept. of Defense Prostate Cancer Grant Reviewer |
Major Collaborative Activities
| Collaborations with with Dr. Roya Khosravi-Far (Dept. of Pathology) Collaborations with Dr. Steven Balk and Dr. Glenn Bubley (Division of Heme/Onc) |
Investigator's Lab Web Site
| Research Lab URL | None listed |
| Harvard Catalyst Site: | Olumi Harvard Catalyst Web Site |
