Per-Olof J Hasselgren, MD,PhD
Staff Physician
Surgery
Contact Information
| Office: | ST-0919 |
| Phone: | 617-667-1810 |
| Fax: | 617-667-2980 |
| Email: | phasselg@bidmc.harvard.edu |
| Address: | 330 Brookline Ave; ST-0919
Boston, MA 02215 |
Areas of Interest
| 2 Metabolic |
Major Research Theme
|
The research in our laboratory is focused on metabolic and inflammatory responses to sepsis and sever injury. In particular, the catabolic response in skeletal muscle has been examined over the last several years. We have found evidence that muscle wasting seen during sepsis and after injury mainly reflects an increase in the breakdown of muscle proteins. We are investigating the molecular regulation of sepsis-induced muscle proteolysis and are particularly interested in the role of the ubiquitin-proteasome proteolytic pathway. An increase in the gene expression and activity of several enzymes regulating the ubiquitination of muscle proteins as well as upregulated gene expression of ubiquitin and the 26S proteasome support the important role of this proteolytic mechanism in catabolic muscle. In other studies we are exporing the role of certain transcription factors, including NF-kB and C/EBP beta, as well as nuclear co-factors, including p300 and PGC-1 alpha and beta, in sepsis- and glucocorticoid-regulated muscle wasting. |
Publications
External Recognition
| Invited speaker Calpain and calpastatin in muscle wasting during sepsis. Cachexia in Aging and Cancer Conference, Chicago, IL, December 2004 Visiting Professor, Department of Surgery and Molecular Biology, Pennsylvania State University, May 2005. Guest Editor, Directed Issue on Muscle Wasting, Int J Biochem Cell Biology, October 2005. Invited speaker Cell signaling in muscle wasting. European Society for Parenteral and Enteral Nutrition (ESPEN), Brussels, Belgium, August 2005. Invited speaker, “Cell signaling in muscle wasting.†European Society for Parenteral and Enteral Nutrition (ESPEN), Brussels, Belgium, August 28-29, 2005 Invited speaker, “Role of transcription factors and nuclear cofactors in muscle wasting.†Round Table Conference, International Conference for Critical Care Medicine, Brussels, Belgium, March 24, 2007 Invited speaker “Glucocorticoids and muscle wasting.†International Conference for Critical Care Medicine, Brussels, Belgium, March 25-28, 2007 Invited speaker “Development of muscle wasting.†International Conference for Critical Care Medicine, Brussels, Belgium, March 25-28, 2007 Invited speaker “Transcription factors and nuclear cofactors in sepsis-induced muscle wastingâ€. International Sepsis Forum 6th Annual Summer Colloqiuium, Annapolis, Maryland, June 8-9, 2007 Invited speaker “Thyroid Nodules – Workup and Surgical Managementâ€. Grand Rounds, Winchester Hospital, Winchester, MA, March 28, 2008 Invited speaker “Transcription factors, nuclear cofactors, and muscle wastingâ€. The Svedberg Lecture Series, Uppsala University, Uppsala, Sweden, May 5, 2008 |
Major Collaborative Activities
| Collaboration in the field of Muscle Wasting with Dr Alfred Goldberg, Porfessor of Cell Biology, HMS, and Dr Stewart Lecker, Associate Professor, Division of Nephrology, Department of mEdicine, BIDMC. |
Investigator's Lab Web Site
| Research Lab URL | None listed |
| Harvard Catalyst Site: | Hasselgren Harvard Catalyst Web Site |
