Yury Popov, MD,PhD
Staff Scientist II
Gastroenterology
Med: Gastroenterology
Contact Information
| Office: | DA-0617C |
| Phone: | 617-667-1269 |
| Fax: | 617-667-2767 |
| Email: | ypopov@bidmc.harvard.edu |
| Address: | 330 Brookline Ave; DA-0617C
Boston, MA 02215 |
Advanced Degree And Training
| Year | Institution | Area or Rank |
| 1992 | Grodno State Medical University, Belarus | MD |
| 1997 | Insitute of Biochemistry, National Academy of Sciences, Belarus | PhD |
| 2001 | University of Erlangen-Nuremberg, Germany | Postdoctoral Fellow |
| 2005 | Beth Israel Deaconess Medical Center, Harvard Medical School | Research Fellow in Medici |
| 2007 | Beth Israel Deaconess Medical Center, Harvard Medical School | Instructor in Medicine |
Areas of Interest
| 1 Cancer | 2 Metabolic |
Major Research Theme
| Our major research focus is on liver fibrosis/cirrhosis. Specifically, we are investigating the basic mechanisms of progression and regression of liver scarring. Our goal is the development of non-invasive diagnostic tools to measure these processes in the clinic, and novel therapies to prevent and reverse cirrhosis and its life-threatening complications. We are actively working on the development, validation and optimization of small animal models for novel drug target discovery and efficacy testing. Some of our current basic research projects include the investigation of a novel macrophage-mediated pathway of fibrosis reversal, role of gut microbes and DAMPs in chronic liver disease, and elucidating the molecular mechanisms of fibrotic matrix stabilization and collagen cross-linking which make liver scarring irreversible. |
Publications
External Recognition
| Young Investigator Award, Foundation for Basic Research, Belarus (1999) Sheila Sherlock Fellowship Award, European Association for the Study of the Liver (2001) Young Investigator Travel Bursary Award, European Association for the Study of the Liver (2003-2007) Presidential Poster of Distinction Award, American Association for the Study of Liver Diseases (2008) Editorial Board Member, American Journal of Physiology: Gastrointestinal and Liver Physiology (2009) Research Grant Reviewer, Israel Science Foundation (2009) Young Investigator Travel Award, American Association for the Study of Liver Diseases (2010) Research Grant Reviewer, Dutch Digestive Disease Foundation (2010, 2011) |
Major Collaborative Activities
| BIDMC, Gastroenterology (Simon Robson) - purinergic signaling as a regulator of biliary and non-biliary liver fibrosis BIDMC, Immunology (Cox Terhorst) - mucosal immunology and gut-liver axis in liver injury and fibrosis Broad Institute, MIT/Harvard (Dirk Gevers) - microbiome in primary sclerosing cholangitis Northeastern Universtity (Konstantin Khrapko) - mtDNA as a danger signal in NASH MIT (Sangeeta Bhatia) - nanoparticle-based tools for non-invasive fibrosis assesment BIDMC, Surgery (Leo Otterbein) - mechanisms of fibrotic liver regeneration Children's Hospital, Surgery (Mark Puder) - MMPs, inflammation and fibrosis in pediatric liver disease |
Investigator's Lab Web Site
| Research Lab URL | None listed |
| Harvard Catalyst Site: | Popov Harvard Catalyst Web Site |
