John T Lamont, MD
Professor
Gastroenterology
Contact Information
| Office: | DA-0501 |
| Phone: | 617-667-8377 |
| Fax: | 617-667-2767 |
| Email: | jlamont@bidmc.harvard.edu |
| Address: | 330 Brookline Ave; DA-0501
Boston, MA 02215 |
Advanced Degree And Training
| Year | Institution | Area or Rank |
| 1965 | Univ of Rochester | Medicine |
| 1971 | Mass General Hospital | Fellow in GI |
| 1975 | Brigham and Women | Asst Prof |
| 1980 | Boston University Med Center | Assoc Prof Chief of GI Di |
| 1985 | Boston Univ | Prof of Medicine |
| 1995 | BIDMC Harvard Med School | Chief of GI Prof of Medic |
Major Research Theme
| We work on the structure and function of Clostridium difficile toxins. These protein exotoxins are among the class of enterotoxins, and they are the main virulence factor for this pathogen , the cause of pseudomembranous colitis. We are trying to elucidate the signal transduction pathways in mammalian enterocytes exposed to toxins A and B of C. difficile. The toxin receptors are surface proteins that help internalize the toxins. Toxin action involves a profound effect on mitocondrial function and activation of protein kinase c.We have also identified a membrane protein that serves as a receptor for C difficie toxins and facilitates cell binding /internalization. |
Publications
External Recognition
| NIH Merit Award 1996-2006 , Assoc Editor NEJM , Past chair, NIH- NIDDK Subcommittee C( Training Grants Review committee). Chair, NIH-NIDDK Boundary Team in Digestive Diseases, Past Senior Assoc Editor, Gastroenterology, Member FDA Review Panel on GI Drugs. |
Major Collaborative Activities
| We interact with laboratories in BIDMC ( Surgery, Endocrinology, Cardiology ) Childrens Hospital, Mass General Hospital, Boston University School of Medicine, University of Chicago and Stanford University School of Medicine |
Investigator's Lab Web Site
| Research Lab URL | None listed |
| Harvard Catalyst Site: | Lamont Harvard Catalyst Web Site |
