photo of Mantzoros, Christos S

Christos S Mantzoros, MD

Professor
Endocrinology
Contact Information
Office:   AN-0249
Phone:   617-667-8630
Fax:   617-667-8634
Email:   cmantzor@bidmc.harvard.edu
Address:    330 Brookline Ave; AN-0249
 Boston, MA 02215
Areas of Interest
2 Metabolic      
Major Research Theme
My group is studying the etiology and treatment of energy homeostasis and the metabolic syndrome with a special emphasis on translational research as well as novel myokines and hepatokines. Some members of the group focus on nonalcoholic steatohepatitis (NASH) whereas others focus on reproductive Endocrinology.
In the laboratory, we use genomic and proteomic approaches to identify new molecules important in energy homeostasis and insulin resistance. We study the mechanisms responsible for regulating energy homeostasis and the development of diabetes using animal models of diabetes and obesity. Moreover, we perform observational studies on determinants and consequences of diabetes, cardiovascular disease and malignancies. We also perform interventional studies in humans to translate discoveries in the laboratory to new diagnostic and therapeutic advances in humans.
The main, but not exclusive, focus of our human studies is currently the physiology, pathophysiology and therapeutic significance of adipokines, including leptin and adiponectin.
External Recognition
Dr. Mantzoros is an internationally recognized expert on obesity and diabetes and has published as an Editor three books (one on Diabetes and Obesity and two on Nutrition and Metabolism with more than two editions each), more than 600 original papers and has received more than 86,000 citations with an h-index of 123.

He has been elected a member of ASCI and a Fellow of the American College of Physicians and the American Association of Clinical Endocrinology. He serves on the Editorial Board of several journals including the Journal of Clinical Endocrinology and Metabolism and has been elected a member of ASCI. He has served as an advisor to Pharmaceutical and Diagnostics companies. He is the scientific co-founder and Chair of the Scientific Advisory Board of InteKrin Metabolic Therapeutics.

He has been given several awards including the prestigious American Association of Clinical Endocrinology Frontiers in Science Award, the Novartis Award in Diabetes and Metabolic Diseases, the Lilly Award by the North American Association for the Study of Obesity, the American Society for Nutrition Mead Johnson Award, the HypoCCS award in Paris, France, the Wilhelm Friedrich Bessel Award by the Humboldt Foundation of Germany, The Hygeia Award of the New England Hellenic Medical and Dental Society and the Outstanding Investigator Award by the American Federation of Medical Research. He is also the recipient of the BIDMC and Harvard Medical School award for excellence in Mentoring and the Berson Award by the American Physiological Society.

Most recently, he has received several prestigious awards for his lifetime achievements: the 2017 Obesity Society TOPS Award, the 2018 Endocrine Society Outstanding Clinical Investigator Award, the 2018 European Society of Endocrinology Geoffrey Harris Prize, and the 2018 American Society of Nutrition Robert H. Herman Award.

Major Collaborative Activities
Collaborative studies with members of several Divisions at BIDMC and the Departments of Epidemiology and Environmental Health at the Harvard School of Public Health as well as the Boston University of Medicine and several other Medical Schools in USA, in Europe (mainly Germany and Greece) and Asia (mainly Korea).
Investigator's Lab Web Site
Research Lab URL     Mantzoros Research Lab
Harvard Catalyst Site:     Mantzoros Harvard Catalyst Web Site