John W Lawler, PhD
Staff Scientist II
Pathology
Contact Information
| Office: | RN-0270K |
| Phone: | 617-667-1694 |
| Fax: | 617-667-3591 |
| Email: | jlawler@bidmc.harvard.edu |
| Address: | 330 Brookline Ave; RN-0270K
Boston, MA 02215 |
Advanced Degree And Training
| Year | Institution | Area or Rank |
| 1976 | Boston College | Physics |
| 1976 | Dana Farber Cancer Institute | Postdoctoral Fellow |
Research Lab Team Members
| Carmelo Nucera MD,PhD | Sareh Parangi MD |
Areas of Interest
| 1 Cancer | 3 Neuroscience |
Major Research Theme
|
The laboratory focuses on the structure and function of the five glycoproteins that comprise the thrombospondin gene family. These proteins are involved in cell-to-cell and cell-to-matrix interactions during the tissue remodeling that is associated with development, wound healing, neoplasia and angiogenesis. The major goal of the research is to elucidate the molecular mechanisms that underlie the inhibition of tumor growth and angiogenesis by thrombospondin-1 and -2. We also seek to understand how the activation of transforming growth factor beta by thrombospondin-1 is regulated. In addition, we are studying the role of mutations in cartilage oligomeric matrix protein (COMP or thrombospondin-5) in pseudoachondroplasia. |
Publications
External Recognition
| 1971-1974, NDEA Title IV Fellowship 1978, NIH, National Research Service Award 1982-1985, NIH, Young Investigator Award 1987, Investigator Recognition Award for Contributions to Hemostasis 1985,'87,'90-'94,'97,'00,'05 Ad hoc reviewer, National Institutes of Health 2007 Harvard Medical School Excellence in Tutoring Award 2000-2006, Vessel Wall Biology II review committee for the American Heart Association (Chairman, 2005, 2006) 2000-2004, American Heart Association, Vascular Wall Biology II, National Peer Review Committee 1987, Speaker, Fibronectin and Related Proteins Gordon Conference 1988, Speaker, Systemes Adhesifs et Functions Cellulaires, France 1989, Speaker, Fibronectin and Related Proteins Gordon Conference 1991, Co-Chair, Subgroup meeting, American Society for Cell Biology 1993, Co-Chair, Integrins and metalloproteinases Session, FASEB 1996, Co-Chair, Subgroup meeting, American Society for Cell Biology 1997, Session Chair, Angiogenesis Gordon Conference 1997, Speaker, Eurpean Cell Biology Organization Meeting, England 1997, Speaker, Atherosclerosis Gordon Conference 1998, Speaker, Interenational Ringberg Symposium, Germany 1999, Speaker, Experimental Biology 99 2002, Speaker, Fourth International Symposium on Anti-angiogenic Agents |
Major Collaborative Activities
| We collaborate with Dr. Jia-huai Wang's group at the Dana Farber Cancer Institute on the determination of the structure of the domains of the thrombospondins by X-ray crystallography. We collaborate with Drs. Laura Benjamin, Harold Dvorak, Ann Dvorak, Roya Khosravi-Far, and Sareh Parangi of the BIDMC in a NIH-funded program project entitled Spatial and Temporal Regulation of Angiogenesis. In addition, we explore the anti-angiogenic activity of thrombospondin-1 in collaboration with Raghu Kalluri. |
Investigator's Lab Web Site
| Research Lab URL | None listed |
| Harvard Catalyst Site: | Lawler Harvard Catalyst Web Site |
