Seth L Alper, MD,PhD
Professor
Nephrology
Contact Information
| Office: | RW-0763 |
| Phone: | 617-667-2930 |
| Fax: | 617-667-0445 |
| Email: | salper@bidmc.harvard.edu |
| Address: | 330 Brookline Ave; RW-0763
Boston, MA 02215 |
Advanced Degree And Training
| Year | Institution | Area or Rank |
| 1980 | Yale | MD PhD |
| 1980 | BIDMC | Professor of Medicine |
Research Lab Team Members
| David Vandorpe PhD |
Areas of Interest
| 1 Cancer |
Major Research Theme
|
My laboratory investigates the molecular physiology of ion transport across the plasma membrane. We are particularly interested in the ways cells regulate their cytoplasmic pH and volume, and exploit these mechanisms in polarized epithelia to accomplish reabsorption and secretion of protons and bicarbonate, of salt and water, and of carboxylates such as oxalate. We develop methods and drugs which can regulate or inhibit these functions to modify the course of disease. Our studies are of importance to the understanding of genetic and acquired diseases of acid-base balance, fluid retention and loss, and ectopic calcification. We have worked with or collaborated on human, rodent, frog, fish, worm, yeast, and bacterial experimental systems. Another theme of the lab is mechanosensitive cellular signaling via Ca entry through nonspecific cation channels. |
Publications
External Recognition
| Interurban Clinical Club 2005 Symposium Organizer and Speaker, 2001 International Union of Physiological Sciences. Symposium Organizer and Spearer, Experimental Biology 2000 Meeting Organizer, NIH Conference on Advances in Membrane Transport: Lessons from Model Organisms, 1999 Fellow of the AAAS, Section on Medical Sciences (N), 1997 Established Investigator of the American Heart Association 1994-9 |
Major Collaborative Activities
| Investigator, Boston Sickle Cell Center Executive Committee and Core Consultant, Harvard DIgestive Diseases Ctr Member, Harvard Cancer Ctr |
Investigator's Lab Web Site
| Research Lab URL | None listed |
| Harvard Catalyst Site: | Alper Harvard Catalyst Web Site |
