Academic and Research Jobs

Academic and Research Jobs at BIDMC.

 
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PostDocComputational Genomics Specialist - Dr. Winston Hide06-May-202131-Aug-2021
As part of the Cure Alzheimers Genome Project, the Hide Laboratory at Beth Israel Deaconess Medical Center seeks a highly motivated person to join our team. As a Computational Genomics Scientist, you will be technically responsible for benchmarking and continuous improvement of our genome analysis pipeline for whole genome sequencing (WGS) of subjects afflicted with Alzheimers. You will manage apprehension, storage, security and delivery of whole genome sequencing data into a cloud environment such as Terra where analysis will take place. You will oversee daily operation of the pipeline and handling of custom analysis, annotation and reporting for BIDMC staff and our collaborators. You should have significant experience in DNA sequencing analysis, including evidence of familiarity with best practice approaches to alignment, variant calling, and structural variant calling. It is important that you have previous experience in cloud-based analyses, preferably at scale. Expertise in Alzheimers disease genetics would be ideal. You will be comfortable with statistical methods for data QC and evaluation and presentation of both production metrics and scientific results. Your successful collaboration with other members of the computational biology team as well as external collaborators and clients is really important to us.

Job duties will include, but are not limited to:
+ Primary technical responsibility for maintenance, improvement, and operation of the WGS analysis pipeline
+ Remaining current with and performing analysis of sequencing data using best practice workflows
+ Development of novel sequence analysis methods where off-the-shelf methods are inadequate
+ Outwards community facing interaction to support / drive best practice
+ Generate and track appropriate quality metrics for high throughput sequencing operations
+ Work with internal staff and collaborators to implement methods or prototype and benchmark customized analysis and annotation pipelines
+ Work with the clinical team to manage transfer of research pipelines to the clinical lab as needed
+ Work with the Broad Institute Terra management team to ensure optimal and efficient use of cloud facilities.
+ Assist, collaborate, and consult with internal/external researchers on analysis of genomic data
+ Interpret and present analysis results to co-workers and collaborators
+ Publish results in scientific journals and give presentations at conferences when possible.

Required Skills:
+ Ph.D. in bioinformatics, computational biology, genetics, computer science or similar
+ Experience in DNA sequencing analysis, including alignment, variant calling, structural variant calling, and interactive exploration of variant information and annotation.
+ Experience in population genetics and genetics of complex traits.
+ Proficiency in utilizing data from public resources such as Genome in a Bottle, 1000 Genomes, ExAC, and GnomAD
+ Proficiency in R, and one or more programming languages such as Python, Perl, Java, or C/C++, willingness to learn new programming languages
+ Experience working in Linux and running tasks in a cluster environment and experience in cloud environments
+ Experience at minimum with sufficient statistical knowledge to develop and interpret standard QC metrics for sequencing
+ Cloud data manipulation/analysis/processing
+ Experience working in teams centered around a biological question and with external collaborators
+ Excellent written and verbal communication skills.

Applications should include a full CV and names of two referees. Please email to whide@bidmc.harvard.edu
PostDocT32 Research Training Fellowship in Resuscitation Science17-Mar-202130-Jun-2021
This is an outstanding training OPPORTUNITY to jump-start an academic career in RESUSCITATION SCIENCE. Funded by an NIH T32 training grant, the Resuscitation Science Fellowship is the only such program focused exclusively on resuscitation nationally. The Resuscitation Science Fellowship is based primarily at Beth Israel Deaconess Medical Center (BIDMC) with collaborations and mentors spanning Massachusetts General Hospital, Brigham and Womens Hospital, Boston Childrens Hospital, MIT, and Boston University Medical Center. This program can be a key early step for junior investigators who wish to pursue academic research in this rapidly growing field.

What is Resuscitation Science? Resuscitation science is a sub-specialty of critical care/emergency medicine focused on understanding the etiology, pathophysiology, and treatment of critical illnesses including sepsis, ARDS, and cardiac arrest.

Program Mission: The overall goal of the program is to train well-rounded junior investigators who intend to continue in academic medicine in the field of resuscitation science.

Program Faculty: Led collaboratively by Drs. Michael Donnino, Murray Mittleman, and Samir Parikh, the 20 program faculty mentors are nationally and/or internationally recognized research leaders whose prolific research laboratories have accounted hundreds of high impact publications, many authored by mentees. They are equally accomplished in training junior investigators, having won numerous teaching awards and serving as primary or secondary research mentors for >80 NIH and foundation mentee-driven training awards.

Program Details:
- Flexibility in training approaches! There are separate tracks for those interested in clinical trials, epidemiology/data science, or laboratory research, but you will gain a good understanding of all 3 approaches.

- Fellows can focus their training on either adult or pediatric resuscitation research

- Didactic component provides a broad background spanning the breadth of resuscitation approaches and disciplines. Didactics includes some core coursework, some optional coursework, as well as research seminars, laboratory meetings, and national conference participation.

- Hands-on research training includes clinical trials and epidemiologic/big data studies for cardiac arrest, sepsis, ARDS, and other areas, as well as pertinent laboratory science investigations using animal models and cutting edge laboratory techniques. Collaborations with fellows and investigators in other track are encouraged.

- Fellows will devote a minimum of 35 hours per week over 2-3 years. 100% protected time for MD fellows. All fellows are expected to apply for an NIH K mentored grant (or foundational equivalent) at the end of their training.

- Fellows will enter at the PGY 1 - PGY 6 salary level depending on their experience and past training

Eligibility and Program Admission Criteria. Eligible MD candidates include physicians specializing in emergency medicine and/or critical care-related disciplines (adult or pediatric) who have completed at least 3 years of residency. Eligible PhD candidates are postdocs interested in epidemiology and translational research pertinent to resuscitation. In either case, the ideal candidate would be seeking NIH funding following completion of this fellowship with the intent of pursuing an academic research career in resuscitation science. Candidates will be evaluated based on past research experience/performance, academic record, and a subjective evaluation of their potential for leadership in resuscitation research. Candidates must be a US citizen or a legal permanent resident of the US.

Contact for more information:
Michael Donnino, MD, Program Director, mdonnino@bidmc.harvard.edu
Francesca Montillo MM, Program Administrator, fmontill@bidmc.harvard.edu
Website: resuscitationscience.com/fellowship-program/
PostDocPostdoc Fellow position in Neuroscience and Neuro-urology - Dr. Verstegen07-Mar-202130-Jun-2021
Postdoctoral Research Fellow position in Neuroscience and Neuro-urology


A postdoctoral position is available in the laboratory of Dr. Anne Verstegen (Beth Israel Deaconess Medical Center and Harvard Medical school) to study the Neural Control of Bladder Function.

The Verstegen Lab focuses on understanding neural control mechanisms for the regulation of physiological behaviors. Examples of research projects are: i) identifying functional neuron subtypes in the micturition reflex pathway, ii) mapping neural circuits involved in maintaining urinary continence and allowing voiding when it is socially appropriate and iii) studying processes by which an organism senses, interprets, integrates, and regulates signals originating from within itself (e.g. bladder fullness).

The position is for a highly motivated individual with considerable experience in biology, neuroscience or related field.
1. Applicants should hold (or will be shortly awarded) a Ph.D. degree in the life/ biological sciences or neuroscience.
2. Experience with animal models is required.

The key priority of the lab is high-quality, fundamental science in a supportive and inclusive environment. In addition, the candidate will benefit from interactions and collaborations with other research groups in the Center for Life Science & Harvard Medical School and be on the frontline of newly emerging cutting-edge technologies.
For more information visit our lab website: Verstegen-Lab.org.

To apply for this position, applicants should email the following to verstegen.lab@gmail.com
- Cover letter with a brief description of current research and a statement of professional goals
- Curriculum Vitae and bibliography
- Contact information of three references
PostDocPostdoc Research Fellow in Human Thyroid Cancers Preclinical and Translational Research- Dr. Nucera23-Feb-202131-Jul-2021
Research Program: Human Thyroid Cancers Preclinical and Translational Research

Beth Israel Deaconess Medical Center, teaching hospital at Harvard Medical School, Boston, USA.

Research topics: We are seeking a highly motivated and enthusiastic post-doctoral research fellow for studies of: advanced research projects regarding the following topics: non coding RNAs, rare thyroid carcinomas, human thyroid cancers preclinical and translational research, BRAFV600E pathways, angiogenesis, inflammation, tumor immunology, tumor microenvironment and tumor metabolism.

Profile: Experienced PhD or MD/PhD are encouraged to apply to be mentored. Candidates need to show strong expertise in cellular and molecular biology, computational science, mouse work, as well as strong enthusiasm for Science. Candidate needs to design and conduct experiments, prepare and present the work at meetings, write scientific manuscripts, and speak fluently in English. Women and minorities are encouraged to apply.

The successful candidate will have the opportunity to collaborate with a large cooperative group of basic, translational, and clinical researchers in the field of Thyroid Cancer Genetics, Pathology, and Vascular Biology.

Please email: CV, copies of any relevant publications, and names/addresses of three possible references to cnucera@bidmc.harvard.edu


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